2006年1月30日 · We show that BMP-4 induces expression of puma in a p53-dependent manner and translocation of bax into the ER, which in turn activates caspase-12 through Ca 2+ release from the ER. Similarly to...

2014年11月13日 · SMAD4 and p53 mutation status and the bone morphogenetic protein (BMP) pathway are known to affect Wnt activity. The combination of SMAD4 loss, p53 mutations and BMP signalling may integrate to...

2018年9月27日 · We investigated the interplay between BMP4/BMPR1A signaling and the ΔNp73 isoform, as this member of the p53 family has been shown to be overexpressed in AML and to regulate CSCs 23,30.

2006年7月1日 · Bone morphogenic protein (BMP)-4 inhibits proliferation and induces the apoptosis of myeloma cells. However, little is known about the molecular mechanisms of how BMP-4 executes this...

2018年9月7日 · BMP4 also interacts with ACSL4 and the p53-signaling pathway, both of which are highly connected to lipid energy metabolism in cancer cells. These findings suggest that BMP4 may be considered a potential prognostic biomarker or therapeutic target for patients with gef-resistant NSCLC.

Instead, BMP4 supplementation triggered apoptosis in the human blastocyst. We focused on P53, which is known to play a major role in the apoptosis. In BMP4-treated embryos, the P53 responsive gene expression was not altered; however, the P53 deacetylase SIRT1 was downregulated and acetylated P53 was increased in mitochondria.

2021年3月25日 · As p53 may be the downstream targets of BMP4, we decided to investigate the role of p53 in ACE induced cancer cell death using wild-type p53 HCT116, mutant p53 DLD-1, and deficient p53 −/− HCT116 cell lines. We examined p53 expression to determine the possible role of p53 in the induction of apoptosis by ACE in these colon cancer cells.

2006年6月15日 · In this report, we investigated the roles of p53 and the endoplasmic reticulum (ER) in BMP-4-induced apoptosis of mouse hybridoma HS-72 cells. We found that 3 ng/ml of BMP-4 is sufficient to induce the expression of proapoptotic proteins, puma and bax, in a p53-dependent mechanism, and facilitate Ca(2+) release from the ER to the cytosol ...

2009年4月3日 · In vitro studies revealed that sublethal oxidative stress increased bone morphogenetic protein-4 expression in retinal pigment epithelial cells, and both bone morphogenetic protein-4 and persistent mild oxidative stress can induce retinal pigment epithelial cell senescence through p53-p21 Cip1/WAF1-Rb pathway.

2016年9月26日 · Here, we show in a Kras LA1/+ p53 R172HΔg/+-based mouse model that bone morphogenetic protein-4 (BMP4) augments the expression of the T cell co-inhibitory receptor ligand PD-L1 in the mesenchymal subset of lung cancer cells, leading to profound CD8 + T cell-mediated immunosuppression, producing tumor growth and metastasis. We previously ...