002101 - p53 KO Strain Details - The Jackson Laboratory
002101 B6.129S2- Trp53 tm1Tyj /J Trp53 knockout mutant mice develop tumors at three to six months of age. They are suitable for use in applications related to the study of familial breast …
Cell | 解锁p53新身份：可作为特定类型神经退行性变的关键调节器 …
2021年1月21日，来自美国斯坦福大学医学院的Aaron D. Gitler和Maya Maor-Nof在Cell杂志上合作发表了一篇题为p53 is a central regulator driving neurodegeneration caused by C9orf72 …
Single loss of a Trp53 allele triggers an increased oxidative, DNA ...
2021年4月6日 · Our results demonstrated that p53 KO imposed a significant increase in MPO activity in circulating leukocytes, spleen and thymus cell populations, whereas loss of a single …
DAXX-ATRX regulation of p53 chromatin binding and DNA …
2022年8月26日 · Here, we show that DAXX and ATRX knock-out (KO) U87-T cells that have acquired ALT-like features have defects in p53 chromatin binding and DNA damage response. …
P53-CKO|p53敲除小鼠|肿瘤发生机制研究|南模生物
南模生物自主研发p53条件性基因敲除小鼠模型（p53-CKO），可与组织特异性Cre工具鼠交配，获得特定组织或细胞中p53纯合缺失小鼠，用于肿瘤发生、机制研究。
Development of p53 knockout U87MG cell line for unbiased drug …
2021年5月20日 · In this study, we created multiple variants of U87MG cells with targeted mutation in the TP53 gene using the CRISPR-Cas9 system, and determined that their major …
Phenotyping analysis of p53 knockout mice produced by gene
2019年4月15日 · In this study, p53 KO mice were produced by gene editing and the phenotypes of tumorigenesis, tumor spectrum, and developmental abnormalities (representative …
Phenotyping analysis of p53 knockout mice produced by gene
Methods: We generated p53 KO mice through gene editing and compared their phenotype with the already reported HR-mediated p53 KO mice. Results: Tumors occurred in 36 (73%) of 49 …
Genes Dev：顾伟实验室解析p53抑癌功能的终极武器——铁死亡 …
2020年12月22日 · 超过一半的肿瘤患者带有p53突变。p53基因敲除 （KO） 小鼠会在发育早期就形成肿瘤。 自从1979年p53基因被发现以来，p53一直是分子生物学和肿瘤学的一个研究热门 …
重新界定铁死亡基本类型：顾伟实验室总结p53在铁死亡调节中的 …
2022年2月14日 · 近日，哥伦比亚大学医学中心 顾伟 教授及其博士后 刘彦卿 博士在 Cell Death & Differentiation 期刊发表了题为： p53 in ferroptosis regulation: the new weapon for the old …