The expression levels of MMP-9 and P53 in serum were detected by fluorescence quantitative Real-Time Polymerase Chain Reaction (RT-PCR). The diagnostic value of MMP-9 and P53 in patients with lung cancer was analyzed by receiver operating characteristic curve (ROC).

Because of p53 overexpression in trophoblastic cells, and its potential role in regulating MMP-2 and MMP-9 expression in different cell lines, we hypothesized that the expression of MMP-9 could also be regulated by p53 in first trimester cytotrophoblasts (CTB).

There was a positive correlation between the expression of MMP-9 and p53 proteins (p<0.05), suggesting that the two proteins likely played a synergistic role in the development and progression of lung cancer metastatic spinal tumor, with the oncogene p53 (wild-type) likely regulating the expression of MMP-9 through negative feedback.

2021年6月14日 · In this review, we discuss the functional relationships between galectin-7, p53 and MMP-9 and reconcile some apparently contradictory observations. A better understanding of these relationships will help to develop a working hypothesis and model that will provide the basis for further research in the hope of establishing a new paradigm for ...

2005年5月16日 · Using MMP inhibitors and MMP-specific small interfering RNA, we show that MMP function confers protection from PKC/p53-induced apoptosis and identify the protective MMPs as MMP-9 and MMP-10. Taken together, these observations provide evidence that MMPs are implicated in tumor cell resistance to the synergistic proapoptotic effect of PKC and p53.

Objectives: p53 mutations and high protein expression are associated with adverse prognosis in several lymphoma subtypes. Matrix metalloproteinase-9 (MMP-9) has also been found to correlate with poor survival in all lymphomas studied.

MMP-9 can cleave many extracellular matrix (ECM) proteins to regulate ECM remodeling. It can also cleave many plasma surface proteins to release them from the cell surface. MMP-9 has been widely found to relate to the pathology of cancers, including but not limited to invasion, metastasis and angiogenesis.

2013年2月15日 · The level of p53, MMP-2 and 9 expressions at IF of the lesions can be helpful in the differentiation of VC and SCC and their histological grading. Among the surveyed markers, MMP-9 can be proposed as the most reliable marker for a more precise grading of oral SCC.

2024年7月17日 · Mechanistically, AGEs interact with RAGE to induce the overexpression of GADD45α through a p53-dependent pathway, leading to GADD45α recruitment to the promoter of MMP-9, where it mediates the demethylation of the MMP-9 promoter through BER, thus participating in the processes of breast cancer cell invasion and metastasis.

含氨基末端前肽PRCGXPD的MMP-9作为酶原合成和分泌，前肽PRCGXPD中半胱氨酸巯基与活性部位的锌螯合，使MMP-9保持潜伏形式。 MMP-9的潜伏形式主要以两种形式存在，一种是单体，另一种是二硫键结合的同型二聚体。 在激活过程中，92kda的潜伏型MMP9经历了两次连续的蛋白裂解。 第一个发生在连接前肽螺旋1和螺旋2的Glu59-Met60键上，产生一个86 kDa的中间形式。 另一个裂解发生在从锌指配位Cys99到下游Arg106-Phe107位置的8个氨基酸残基，产生82 …