PTEN was required for p53-mediated apoptosis in immortalized mouse embryonic fibroblasts. Our results reveal a unique role for p53 in regulation of cellular survival and an interesting …

2003年2月1日 · We show in this study that PTEN regulates p53 protein levels and transcriptional activity through both phosphatase-dependent and -independent mechanisms. The onset of …

2003年2月1日 · Mutations of PTEN and p53 are very frequent, yet often mutually exclusive due to functional interdependence of the proteins and, according to a new study, the most intimate …

The p53 protein cooperates with PTEN and might be an essential blockage in development of mammary tumors. Many findings have demonstrated that PTEN as well as p53 plays a critical …

2005年8月4日 · Our results demonstrate the relevance of cellular senescence in restricting tumorigenesis in vivo and support a model for cooperative tumour suppression in which p53 is …

2000年12月1日 · Our results reveal a unique role for p53 in regulation of cellular survival and an interesting connection in tumor suppressor signaling. Mutations of Pten are frequently found in …

Several studies have demonstrated that PTEN can activate p53 through direct and indirect protein-protein interactions, including phosphatase-dependent and -independent mechanisms …

2008年10月23日 · Here we show that concomitant central nervous system (CNS)-specific deletion of p53 and Pten in the mouse CNS generates a penetrant acute-onset high-grade malignant …

By virtue of its capacity to protect p53, PTEN can sensitize tumor cells to chemotherapy that relies on p53 activity. p53 induces PTEN gene expression, and here it is shown that PTEN protects …

摘要: 目的：旨在分析53抑癌基因 (p53)、张力蛋白同源物 (PTEN)及错配修复蛋白 (MMR)在子宫内膜癌 (EC)组织中的表达，并探讨三种因子与EC临床病理特征的关系。 方法：采用免疫组化方 …