2024年5月10日 · PTM对p53的影响包括改变其蛋白质水平、细胞定位、cofactor招募、靶基因选择性，甚至蛋白质聚集。 其中，泛素化、磷酸化和乙酰化在影响p53功能方面最常见且最有影响力。

Targeting PTM–reader interplay has been developing into a promising cancer therapeutic strategy. In this review, we summarize the advances in deciphering the ‘PTM codes’ of p53, focusing particularly on the mechanisms by which the specific reader proteins functionally decipher the information harbored within these PTMs of p53.

2022年1月21日 · Targeting PTM-reader interplay has been developing into a promising cancer therapeutic strategy. In this review, we summarize the advances in deciphering the 'PTM codes' of p53, focusing particularly on the mechanisms by which the specific reader proteins functionally decipher the information harbored within these PTMs of p53.

肿瘤抑制因子p53在约50%的人类恶性肿瘤中发生突变，拥有300多个ptm位点。30多种e3连接酶泛素化p53，对其稳定性具有不同的影响，最经典途径：单个e3连接酶mdm2在残基18-28处结合p53的n末端并将其泛素化在六个c末端赖氨酸上，从而将蛋白质运送到ups。

本文主要综述了p53一些典型PTM调控，着重强调多种修饰可以共同作用于p53使其产生更复杂的功能，除此之外，还对通过靶向p53修饰途径来治疗疾病做了简短讨论。

在p53-null肿瘤中，提供p53蛋白、mRNA和DNA可以恢复p53表达并消灭肿瘤细胞。 总之，P53 蛋白是一种转录因子和肿瘤抑制蛋白，可结合 DNA 并调控多种转录靶标，响应细胞应激或 DNA 损伤，协调细胞周期阻滞、DNA 修复、代谢改变、凋亡等过程，防止肿瘤形成。

2024年6月14日 · 为了引起P53乳酰化的蛋白质，作者进行了全基因组CRISPR筛查。结果显示，Alanyl-tRNA synthttase 1(AARS1)是差异最为显著的基因。进一步实验表明，AARS1缺失提高了P53的表达，并对乳酸诱导的抑制的反应变得不敏感。

2024年5月9日 · Many PTMs of p53 are reversible. The overall effect of PTMs on p53 includes altering its protein level, cellular localization, cofactor recruitment, target selectivity, and even protein aggregation. 21,29,30 Among these, ubiquitination, phosphorylation, and acetylation are the most common and influential in affecting p53 activity.

Transcriptional levels of p53 downstream target genes can be generally increased by p53 nuclear accumulation and the release of chromatin-bound p53 from repression state. On the other hand, selective functions of p53 can be fulfilled through enhancement of p53's transactivation of specific target genes 19 .

2019年7月19日 · The exquisite regulation of p53 functions is of vital importance for cell fate decisions. Among the multiple layers of mechanisms controlling p53 function, posttranslational modifications (PTMs) represent an efficient and precise way. Major p53 PTMs include phosphorylation, ubiquitination, acetylation, and methylation.