p53, also known as Tumor protein P53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory protein that is often mutated in human cancers. The p53 proteins (originally thought to be, and often spoken of as, a single protein) are crucial in vertebrates , where they prevent cancer formation. [ 5 ]

p53是一系列被称为腫瘤抑制蛋白（也稱為p53蛋白或p53腫瘤蛋白）的同源异构蛋白的统称。由TP53（人体）及Trp53（老鼠）基因编码。该蛋白是最早发现的肿瘤抑制基因所编码的蛋白之一。

p53是一系列被稱為腫瘤抑制蛋白（也稱為p53蛋白或p53腫瘤蛋白）的同源異構蛋白的統稱。由TP53（人體）及Trp53（老鼠）基因編碼。該蛋白是最早發現的腫瘤抑制基因所編碼的蛋白之一。

p53是一系列被称为腫瘤抑制蛋白（也稱為p53蛋白或p53腫瘤蛋白）的同源异构蛋白的统称。由TP53（人体）及Trp53（老鼠）基因编码。该蛋白是最早发现的肿瘤抑制基因所编码的蛋白之一。

La P53, anche conosciuta come proteina tumorale 53 (gene TP53), è un fattore di trascrizione che regola il ciclo cellulare e ricopre la funzione di soppressore tumorale. La sua funzione è particolarmente importante negli organismi pluricellulari per sopprimere i tumori nascenti.

p53 es una proteína supresora de tumores. 1 En la especie humana, el gen p53 o TP 53, también llamado el guardián del genoma, se encuentra en el brazo corto del Cromosoma 17 (humano) (17p13) y codifica un factor de transcripción nuclear de 43,7 K Da. Su nombre hace referencia a su masa molecular aparente: corre como una proteína de 53 KDa en u...

Le p53 (ou TP53 pour « tumor protein 53 »), parfois surnommée « gardienne du génome », est un facteur de transcription découvert en 1979 qui se lie à l'ADN pour réguler de multiples fonctions cellulaires importantes comme la régulation du cycle cellulaire, l'autophagie ou l'apoptose (mort cellulaire programmée).

p53最早在软骨鱼基因组的p63/p73基因重複中分化出来 [4] ，p63/p73此后在硬骨鱼中再分化为p63和p73 [4] 。 后来它们各自发展出了不同的结构与功能，最终形成了可以区分的三个基因— TP63 、 p73 、 p53 。

p53 (or tp53) is a gene vital to many forms of life, including humans. It codes for a protein which suppresses cancer. It has been called "the guardian of the genome ". [1] The p53 gene is the most frequently mutated gene (>50%) in human cancer. [2] . Its protein product binds to DNA and regulates gene expression to prevent mutations of the genome.

The p53 p63 p73 family is a family of tumor suppressor genes. [1] [2] This gene family codes the proteins: p53; TP73L (also known as "p63") p73; They are sometimes considered part of a "p53 family." When overexpressed, these proteins are known to be involved in tumor pathogenesis. [3]