Jun 27, 2016 · Phosphorylated p62/Sqstm1 accumulates in tumour regions positive for hepatitis C virus (HCV). An inhibitor of phosphorylated p62-dependent Nrf2 activation suppresses the …

Jun 15, 2017 · Our findings show how p62 helps maintain intracellular pools of GSH needed to limit mitochondrial dysfunction in tumor cells with elevated mTORC1, highlighting p62 and …

Aug 1, 2012 · In our study, we found that HT increases p62 mRNA and protein levels dose dependently; we also found that regulation of p62 accumulation is not involved in autophagy. …

Feb 1, 2025 · Mechanically, SFN directly targeted p62 protein and enhanced p62/SLC7A11 protein-protein interaction, thereby promoting the lysosomal degradation of SLC7A11 and …

SQSTM1/p62 (sequestosome 1) is a multifunctional signaling molecule, involved in a variety of cellular pathways. SQSTM1 is one of the best-known autophagic substrates, and is therefore …

Jun 6, 2017 · Metabolic profiling revealed that depletion of p62 in Tsc2-null cells decreased intracellular glutamine, glutamate, and glutathione (GSH). p62 positively regulated the …

SQSTM1/p62 是由SQSTM1基因编码的一种多功能泛素化结合的接头蛋白,参与泛素蛋白酶体系统和自噬-溶酶体系统两种蛋白质降解过程,同时具有质核穿梭功能,在DNA损伤修复和氧化应激反 …

Nov 16, 2021 · We found markedly increased hepatic levels of p62 at 24 h after APAP treatment, which is correlated with increased NRF2 target gene expression and hepatic GSH recovery. In …

Apr 2, 2025 · By delineating how ferroptosis markers—Fe 2*, MDA, GSH, and GPX4—are regulated in tandem with p62/Nrf2 activation, we demonstrate a previously unrecognized …

CDGSH 铁硫结构域 2 (CISD2) 是一种具有 [2Fe-2S] 簇的铁硫蛋白，对于细胞增殖和铁稳态至关重要。 已证明 CISD2 的异常表达与多种癌症的进展相关。 然而，CISD2 调节肿瘤发生的潜在 …