2024年2月14日 · Adult lung resident stem/progenitor cells, including P63 + progenitor cells, have demonstrated the capacity for regeneration of lung epithelium in preclinical models. Here, we report a clinical trial of intrapulmonary P63 + progenitor cell transplantation in 28 participants with …

2024年11月7日 · Our study identifies secretory-cell-derived p63 + progenitors as contributors to alveolar repair, suggesting a potential therapeutic avenue for lung regeneration following injury. Efficient gas exchange in the lung depends on the delicate organization, integrity, and function of diverse types of epithelial cells.

2024年9月5日 · 为了解析肺上皮细胞参与修复的动态过程，研究人员利用博莱霉素诱导的肺泡上皮损伤模型，意外发现气道上皮基底干细胞的标志基因 p63 在损伤后的肺泡区域显著表达。 为了追踪这群独特的 p63 +细胞的命运轨迹，研究人员构建了p63-CreER工具鼠模型，发现这群 p63 +细胞在损伤后出现，明确界定出这群细胞不同于气道基底干细胞以及远端气道中的 p63 +细胞。 进一步研究发现，这群细胞具有较强的增殖能力与向 AT1 细胞和 AT2 细胞广泛分化的能力，提示 …

2024年2月14日 · P63 + lung progenitor cells can be easily isolated, expanded, and transplanted for lung regeneration. This study demonstrated the feasibility and safety of bronchoscopic administration of P63 + lung progenitor cells in patients with COPD.

2025年2月3日 · Here we show that in murine and monkey models, the KRT5 + P63 + progenitor cells in airway basal layer can enter the alveolar area post fibrotic injury. Aided with an automated culture system, we...

2024年12月13日 · After 3-5 weeks of cell expansion, up to 100 million P63+ lung progenitor cells were produced and transplanted into the lungs of IPF patients via bronchoscopy. The safety and potential efficacy of this novel cell therapy for treating IPF were addressed in this clinical trial.

2024年11月19日 · In order to study whether the autologous P63 + progenitor cells could repair the bronchiectasis lung, we conducted a single-blind, randomized, controlled clinical trial (NCT03655808) between June 2020 to May 2023, to investigate the effect of P63 + progenitor cells on parenchyma repair in patients with bronchiectasis, which were diagnosed ...

Ref. 14). In contrast, p63+ stem cells from distal lung differentiate to epithelia replete with Club, AT2, and AT1 markers. The spectrum of p63+ stem cells in the normal bronchi of any generation is less studied. In the present study, cells are obtained by bronchoscopy from 3-5 generation bronchi and expanded by in vitro propagation.

2024年11月19日 · Non-cystic fibrosis bronchiectasis is a progressive respiratory disease with limited treatment options, prompting the exploration of regenerative therapies. This study investigates the safety and efficacy of autologous P63 + progenitor cell transplantation in a randomized, single-blind, co …

2024年11月19日 · Yan et al. demonstrate that autologous P63+ progenitor cell transplantation enhances lung gas exchange function, quality of life, CT imaging outcomes, and bronchiectasis severity scores in patients with bronchiectasis.