K48/K63-linked polyubiquitination of ATG9A by TRAF6 E3 ligase …
2022年2月22日 · We found that after LPS treatment, ablation of ATG9A caused a marked decrease in the phosphorylation of JNK but not IκB kinase (IKK) or p65, compared with the …
K48、K63泛素蛋白质粒表达出来的泛素有何不同？-丁香实验
2025年1月21日 · k48和k63经常是多聚泛素化的最主要的两种形式，通过k48连接的多聚泛素化通常会导致蛋白酶体介导的蛋白降解，k63连接的多聚泛素化可以参与信号调节，对很多信号通 …
Post-translational modifications of p65: state of the art
2024年7月9日 · Deletion of PPARγ in murine embryonic fibroblasts resulted in increased stability of p65. Conversely, overexpression of PPARγ led to ubiquitination of p65 at the K48 site, …
TRIM21 interacts with IκBα and negatively regulates
TRIM21 interacted with IκBα by PRY/SPRY domain, stabilizes IκBα and negatively regulates IκBα phosphorylation in macrophages during C. pseudotuberculosis infection. In addition, TRIM21 …
Targeting TRAF6/IRF3 axis to inhibit NF-κB-p65 nuclear ... - PubMed
2024年12月20日 · Low expression of TRAF6 inhibited nuclear translocation of NF-κB-p65, which was achieved by promoting the expression of Interferon regulatory factor 3 (IRF3). Importantly, …
The E3 ubiquitin ligase RNF182 inhibits TLR-triggered cytokine ...
2019年8月21日 · Mechanistically, RNF182 promotes the degradation of p65 via K48-linked ubiquitination, resulting in the inhibition of TLR-triggered innate immune responses. Our …
靶点解惑Plus | NF-κB p65, p62和 Nrf2信号通路详解，剖析氧化应 …
NF-κB p65 是NF-κB家族成员之一，NF-κB是一种多效性转录因子，几乎存在于所有细胞类型中，并参与许多生物学过程，例如炎症、免疫、分化、细胞生长、肿瘤发生和凋亡。 NF-κB受翻 …
FR promotes the K48-linked ubiquitination of p65 by
FR promotes the K48-linked ubiquitination of p65 by recruiting the E3 ubiquitin enzyme RNF182. Tenocytes were silenced with RNF182 siRNA (A), ING4 siRNA (B), or PPARγ siRNA (C) for …
K48/K63-linked polyubiquitination of ATG9A by TRAF6 E3
2022年2月22日 · We find that, upon ROS stimulation, TRAF6 mediates K48/K63-linked ubiquitination of ATG9A, enhancing ATG9A-Beclin 1 interaction, PI3KC3/VPS34 activity, and …
FR promotes the K48-linked ubiquitination of p65 in
... we found that FR specifically increased K48-linked (K48-only ubiquitin mutant) poly-ubiquitination of p65, but not the ubiquitination of p65 with other ubiquitin linkages in an...