2016年8月23日 · We investigated the contribution of the phosphorylation of the NF-κB subunit p65 at the IKK phosphorylation site serine 536 (Ser(536)) in humans, which is thought to be …

2005年10月14日 · Here we demonstrate that the regulation of nuclear translocation of p65 phosphorylated at serine 536 is not dependent on IkappaBalpha. Stimulation of either Jurkat …

Here we demonstrate that the regulation of nuclear translocation of p65 phosphorylated at serine 536 is not dependent on IκBα. Stimulation of either Jurkat or normal human T cells resulted in …

2021年8月11日 · We found that p65 Ser536, but not Ser276 or Ser529, was markedly phosphorylated after ARRB1 overexpression in HepG2 and Hep3B cells (Fig. 5a). These …

2024年9月8日 · Recently, a novel transcriptional regulatory mechanism of NF-κB involving the phosphorylation of serine 536 (534 in mice; S534) of its p65 subunit was reported; however, …

2024年11月4日 · In vivo experiments demonstrated that a phosphorylation-mimetic mutant of RelA/p65 Ser536 (p65/S536D) prevents tumor progression and metastasis. In vitro …

Ser 536 (S536) of the p65 subunit represents the site with the most potent inducible phosphorylation in response to inflammatory stimuli (9), and it is highly conserved among …

2024年11月4日 · In vivo experiments demonstrated that a phosphorylation-mimetic mutant of RelA/p65 Ser536 (p65/S536D) prevents tumor progression and metastasis. In vitro …

2016年8月23日 · Together, our results suggest that Ser 534 phosphorylation of p65 in mice (and, by extension, Ser 536 phosphorylation of human p65) is not required for its nuclear …

2015年9月16日 · This study shows that phosphomimetic mutation of RelA/p65 at the Ser536 residue results in dramatic death and senescence of breast, colon, and prostate cancer cells in …