Ubiquitination of NF-κB p65 by FBXW2 suppresses breast cancer …
2021年8月31日 · Here, we find that nuclear factor-kB (NF-κB) p65 is a new substrate of FBXW2. FBXW2 directly binds to p65, leading to its ubiquitination and degradation. Interestingly, p300 …
Proposition 65 Warnings Website - Your right to know
Proposition 65 warnings advise of exposures to chemicals that may contribute to an individual's overall lifetime risk of cancer or risk of birth defects or other reproductive harm. If a warning is …
Unconventional p65/p52 NF-κB module regulates key tumor ...
2024年11月15日 · In the present study, we demonstrated its enhanced active nuclear localization in TAMs and validated selected immune target genes as directly regulated by dimer binding on …
Mechanisms of NF-κB p65 and strategies for therapeutic …
Hence, the NF-κB p65 signaling pathway has been a pivotal point for intense drug discovery and development. This review begins with an overview of p65-mediated signaling followed by …
靶点解惑Plus | NF-κB p65, p62和 Nrf2信号通路详解，剖析氧化应 …
NF-κB p65 是NF-κB家族成员之一，NF-κB是一种多效性转录因子，几乎存在于所有细胞类型中，并参与许多生物学过程，例如炎症、免疫、分化、细胞生长、肿瘤发生和凋亡。 NF-κB受翻 …
PAI-1-driven SFRP2high cancer-associated fibroblasts hijack the ...
3 天之前 · Serum proteomics reveals that irradiated-tumor-secreted PAI-1 triggers distant tumor pericyte cell-fate transition into SFRP2 high CAFs via the LRP1/p65 axis. Pharmacologically …
Regulation of p65 nuclear localization and chromatin states by ...
2025年2月5日 · The tumor microenvironment is a dynamic ecosystem, that evolves with the developing tumor to support its growth and metastasis. A key aspect of TME evolution is the …
Type I Diabetes Mellitus impairs cytotoxic immunity through …
2024年10月18日 · Our findings demonstrate that the NF-κB p65 subunit plays a crucial role in promoting tumor growth and modulating the immune microenvironment in CRC, particularly in …
核因子-κB p65在肝细胞癌中的表达及意义 - lcgdbzz.org
The key to the regulation of NF-κB function is to inhibit the promotional effect of Rel A ( p65) on liver tumor. Therefore, inhibiting the activity of NF-κB p65 may suppress the differentiation and …
Inhibition of DEF‐p65 Interactions as a Potential Avenue to …
2024年5月17日 · Analysis of clinical samples reveals that high expression of DEF is correlated with diminished survival in pancreatic cancer patients. Crucially, the depletion of DEF …