2023年10月26日 · To enhance the therapeutic effect of buformin, six p65 siRNA molecules are loaded onto the DNA nanoprism. Both buformin and p65 siRNA demonstrated remarkable …

2017年3月30日 · Here, we show that RelA/p65 functions as a core fibrogenic regulator in tendon adhesion and that its inhibition exerts an anti-fibrogenic effect on peritendinous adhesion.

2007年5月25日 · Effective knockdown of NF-κB p65 in FLSs by REL1096 siRNA. To isolate a highly efficient siRNA targeting NF-κB p65, we have designed 30 siRNA candidates using our …

The p5RHH-p65 siRNA nanocomplexes potently suppressed early inflammatory arthritis without affecting p65 expression in off-target organs or eliciting a humoral response after serial injections.

2017年4月5日 · Using yeast two-hybrid screening, we sought to isolate PDLIM2-interacting proteins that are critical for suppressing NF-κB signaling. Here we identified MKRN2, a RING …

In the present study, reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) and western blotting were used to detect the NF‑κB p65 mRNA and protein expression at different …

2019年1月24日 · Herein, we used a self-assembling peptidic nanoparticle (NP) platform featuring a cell penetrating peptide complexed to NF-κB p65 siRNA. We show that it efficiently and …

SignalSilence ® NF-kappaB p65 siRNA from Cell Signaling Technology allows the researcher to specifically inhibit NF-kappaB p65 expression using RNA interference, a method in which gene …

2022年2月15日 · Here, we assess the impact of silica-coated calcium phosphate nanoparticles carrying encapsulated siRNA against NF-κB p65 on a murine model of colitis. To this end, …

2025年3月4日 · Tlr4 siRNA transfection significantly reduced Tlr4 expression in the absence and presence of LPS, respectively (fig. S4A). ... Levels of acetylated (ac-p65) and unacetylated …