
p65 siRNA-Loaded Buformin/DNA Nanoprisms Alleviate Acute …
2023年10月26日 · To enhance the therapeutic effect of buformin, six p65 siRNA molecules are loaded onto the DNA nanoprism. Both buformin and p65 siRNA demonstrated remarkable inhibition of NLRP3-mediated pyroptosis.
RelA/p65 inhibition prevents tendon adhesion by modulating
2017年3月30日 · Here, we show that RelA/p65 functions as a core fibrogenic regulator in tendon adhesion and that its inhibition exerts an anti-fibrogenic effect on peritendinous adhesion.
Dual knockdown of p65 and p50 subunits of NF-kappaB by siRNA …
2007年5月25日 · Effective knockdown of NF-κB p65 in FLSs by REL1096 siRNA. To isolate a highly efficient siRNA targeting NF-κB p65, we have designed 30 siRNA candidates using our proprietary siRNA design program called Turbo si-Designer (Bioneer, Republic of Korea).
Peptide-siRNA nanocomplexes targeting NF-κB subunit p65 …
The p5RHH-p65 siRNA nanocomplexes potently suppressed early inflammatory arthritis without affecting p65 expression in off-target organs or eliciting a humoral response after serial injections.
MKRN2 is a novel ubiquitin E3 ligase for the p65 subunit of NF-κB …
2017年4月5日 · Using yeast two-hybrid screening, we sought to isolate PDLIM2-interacting proteins that are critical for suppressing NF-κB signaling. Here we identified MKRN2, a RING finger domain-containing...
SiRNA directed against NF‑κB inhibits mononuclear ... - PubMed
In the present study, reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) and western blotting were used to detect the NF‑κB p65 mRNA and protein expression at different times in THP‑1 cells infected by p65 siRNA retroviruses.
Development of a peptide-siRNA nanocomplex targeting NF
2019年1月24日 · Herein, we used a self-assembling peptidic nanoparticle (NP) platform featuring a cell penetrating peptide complexed to NF-κB p65 siRNA. We show that it efficiently and deeply penetrated human...
SignalSilence ® NF-κB p65 siRNA I #6261 - Cell Signaling …
SignalSilence ® NF-kappaB p65 siRNA from Cell Signaling Technology allows the researcher to specifically inhibit NF-kappaB p65 expression using RNA interference, a method in which gene expression can be selectively silenced through the delivery …
Nanoparticles Carrying NF-κB p65-Specific siRNA Alleviate Colitis …
2022年2月15日 · Here, we assess the impact of silica-coated calcium phosphate nanoparticles carrying encapsulated siRNA against NF-κB p65 on a murine model of colitis. To this end, nanoparticles were injected intravenously (2.0 mg siRNA/kg body weight) into mice after colitis induction with dextran sulfate sodium or healthy ones.
The acetyltransferase GCN5 contributes to ... - Science | AAAS
2025年3月4日 · Tlr4 siRNA transfection significantly reduced Tlr4 expression in the absence and presence of LPS, respectively (fig. S4A). ... Levels of acetylated (ac-p65) and unacetylated (p65) NF-κB p65 protein in the whole brain, cortex, and hippocampus were determined 6 hours after LPS administration by WB assays. β-Actin was used as the internal control.
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