2023年10月26日 · To enhance the therapeutic effect of buformin, six p65 siRNA molecules are loaded onto the DNA nanoprism. Both buformin and p65 siRNA demonstrated remarkable inhibition of NLRP3-mediated pyroptosis.

2017年3月30日 · Here, we show that RelA/p65 functions as a core fibrogenic regulator in tendon adhesion and that its inhibition exerts an anti-fibrogenic effect on peritendinous adhesion.

2007年5月25日 · Effective knockdown of NF-κB p65 in FLSs by REL1096 siRNA. To isolate a highly efficient siRNA targeting NF-κB p65, we have designed 30 siRNA candidates using our proprietary siRNA design program called Turbo si-Designer (Bioneer, Republic of Korea).

The p5RHH-p65 siRNA nanocomplexes potently suppressed early inflammatory arthritis without affecting p65 expression in off-target organs or eliciting a humoral response after serial injections.

2017年4月5日 · Using yeast two-hybrid screening, we sought to isolate PDLIM2-interacting proteins that are critical for suppressing NF-κB signaling. Here we identified MKRN2, a RING finger domain-containing...

In the present study, reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) and western blotting were used to detect the NF‑κB p65 mRNA and protein expression at different times in THP‑1 cells infected by p65 siRNA retroviruses.

2019年1月24日 · Herein, we used a self-assembling peptidic nanoparticle (NP) platform featuring a cell penetrating peptide complexed to NF-κB p65 siRNA. We show that it efficiently and deeply penetrated human...

SignalSilence ® NF-kappaB p65 siRNA from Cell Signaling Technology allows the researcher to specifically inhibit NF-kappaB p65 expression using RNA interference, a method in which gene expression can be selectively silenced through the delivery …

2022年2月15日 · Here, we assess the impact of silica-coated calcium phosphate nanoparticles carrying encapsulated siRNA against NF-κB p65 on a murine model of colitis. To this end, nanoparticles were injected intravenously (2.0 mg siRNA/kg body weight) into mice after colitis induction with dextran sulfate sodium or healthy ones.

2025年3月4日 · Tlr4 siRNA transfection significantly reduced Tlr4 expression in the absence and presence of LPS, respectively (fig. S4A). ... Levels of acetylated (ac-p65) and unacetylated (p65) NF-κB p65 protein in the whole brain, cortex, and hippocampus were determined 6 hours after LPS administration by WB assays. β-Actin was used as the internal control.