The NADPH oxidase cytosolic component p67phox is …
2011年11月1日 · The cytosolic NADPH oxidase component, p67phox, has been shown to be phosphorylated in human neutrophils but the pathways involved in this process are largely …
The NADPH Oxidase Activator p67phox and Its Related Proteins
2023年6月23日 · Here we describe how p67 phox as well as its homologues functions in activation of EF-hand-independent oxidases at the molecular level. The Nox family of …
The NADPH oxidase cytosolic component p67phox is …
2011年11月1日 · Neutrophils play a key role in host defense and inflammation through the production of superoxide anion and other reactive oxygen species (ROS) by the enzyme …
Neutrophil cytosolic factor 2 - Wikipedia
17970 Ensembl ENSG00000116701 ENSMUSG00000026480 UniProt P19878 O70145 RefSeq (mRNA) NM_000433 NM_001127651 NM_001190789 NM_001190794 NM_010877 RefSeq …
Regulation of the phagocyte NADPH oxidase activity: …
Neutrophils generate microbicidal oxidants through activation of a multicomponent enzyme called NADPH oxidase. During activation, the cytosolic NADPH oxidase components (p47phox, …
The major phosphorylation site of the NADPH oxidase component p67phox …
2001年1月1日 · Phosphorylation of p67phox was shown to increase two- to three-fold upon stimulation by PMA, N-formylmethionyl-leucylphenylalanine or serum-opsonized zymosan. …
p67phox terminates the phospholipase A2-derived signal for …
We found that the interaction of p67 phox with phosphorylated Prdx6 (phosphoPrdx6) inhibits the PLA 2 activity of the enzyme, consistent with a consequent termination of the initiating signal …
The IRAK-ERK-p67phox-Nox-2 axis mediates TLR4, 2-induced …
2015年8月31日 · In the present study, we demonstrate that the TLR4- and TLR2-induced IRAK-ERK pathway cross-talks with p67phox-Nox-2 for ROS generation, thus regulating IL-1β …
p67phox -derived self-assembled peptides prevent Nox2 NADPH …
In this study, we found that: (i) progressive N- and C-terminal truncation of inhibitory p67 phox peptides, corresponding to residues 259-273 and 265-279, revealed that inhibitory ability …
Regulation of the phagocyte NADPH oxidase activity ... - PubMed
During neutrophil stimulation, p47 (phox), p67 (phox), p40 (phox), and p22 (phox) are phosphorylated; however, the phosphorylation of gp91 (phox)/NOX2 and its potential role have …