Ribosomal protein S6 kinase beta-1 (S6K1), also known as p70S6 kinase (p70S6K, p70-S6K), is an enzyme (specifically, a protein kinase) that in humans is encoded by the RPS6KB1 gene. [5] [6] It is a serine/threonine kinase that acts downstream of PIP3 and phosphoinositide-dependent kinase-1 in the PI3 kinase pathway. [7]

p70核糖体s6激酶 (s6k) 和真核起始因子eif4e的结合蛋白 4ebp。 它们各自通过下游的效应子来分别促进帽依赖的翻译及EJC相关的翻译。 其中S6K的激活会磷酸化并降解胰岛素受体底物IRS1，从而形成了一个负反馈调节。

2024年12月4日 · p70核糖体蛋白S6激酶（p70S6K），全称为70 kDa ribosomal protein S6 kinase，是一种丝氨酸/苏氨酸蛋白激酶，属于AGC激酶家族。 p70S6K在细胞内扮演着重要的信号传导角色，尤其是在mTOR（哺乳动物雷帕霉素靶蛋白）信号通路中，作为mTOR的主要下游效应 …

经专家审核且提供 eIF4E 和 p70 S6K 调控最新概述的相互作用通路。

2022年6月1日 · p70 S6 kinase (p70 S6K ) is best known for its regulatory roles in protein synthesis and cell growth by phosphorylating its primary substrate, ribosomal protein S6, upon mitogen stimulation. The enhanced expression/activation of p70 S6K has been correlated with poor prognosis in s …

The Rps6kb1 gene encodes the 70 kDa ribosomal protein S6 kinase (p70S6K), which is a serine/threonine kinase regulated by phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) pathway. p70S6K plays a crucial role …

p70 S6 kinase (p70S6K), a member of the AGC serine/threonine kinase family, was initially identified as a key player, together with its downstream effector S6, in the regulation of cellular growth and survival. The p70S6K protein has emerged in ...

p70 S6 kinase is a mitogen activated Ser/Thr protein kinase that is required for cell growth and G1 cell cycle progression (1,2). p70 S6 kinase phosphorylates the S6 protein of the 40S ribosomal subunit and is involved in translational control of 5' oligopyrimidine tract mRNAs (1).

Expert-reviewed interactive pathway providing a current overview of Regulation of eIF4E and p70 S6K.

The Rps6kb1 gene encodes the 70 kDa ribosomal protein S6 kinase (p70S6K), which is a serine/threonine kinase regulated by phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) pathway. p70S6K plays a crucial role …