PAF-Wnt signaling-induced cell plasticity is required for ... - Nature
2016年2月4日 · In this study, we found that the proliferating cell nuclear antigen-associated factor (PAF)-Wnt signalling axis converts normal epithelial cells into CSC-like (CSL) cells. PAF (also …
PAF and EZH2 Induce Wnt/β-Catenin Signaling Hyperactivation
2013年10月10日 · Fine-control of Wnt signaling is essential for various cellular and developmental decision making processes. However, deregulation of Wnt signaling leads to pathological …
PAF and EZH2 induce Wnt/β-catenin signaling hyperactivation
2013年10月24日 · In mice, conditional expression of PAF induces intestinal neoplasia via Wnt signaling hyperactivation. Our studies reveal an unexpected role of PAF in regulating Wnt …
proliferating cell nuclear antigen-associated factor (PAF)-Wnt signalling axis converts normal epithelial cells into CSC-like (CSL) cells. PAF (also...
PAF Makes It EZ(H2) for β-Catenin Transactivation - Cell Press
2013年10月24日 · In mouse embryos, PAF is highly expressed in regions known for Wnt/β-catenin signaling such as the apical ectodermal ridge of the limb bud. Therefore, PAF appears …
PAF-Wnt signaling-induced cell plasticity is required for …
2016年2月4日 · In MECs, ectopic expression of PAF induces anchorage-independent cell growth and breast CSC marker expression. In mouse models, conditional PAF expression induces …
PAF-Wnt信号传导诱导的细胞可塑性是维持乳腺癌细胞干性所必需 …
此外，PAF表达通过Wnt信号传导使MEC具有自我更新的能力和细胞异质性的产生。 相反，内源性PAF的消融诱导了乳腺癌细胞干性的丧失。 进一步的抗癌药物重用方法表明NVP-AUY922下 …
PAF-Wnt signaling-induced cell plasticity is required for …
In this study, we found that the proliferating cell nuclear antigen-associated factor (PAF)-Wnt signalling axis converts normal epithelial cells into CSC-like (CSL) cells. PAF (also known as …
PAF-AH Catalytic Subunits Modulate the Wnt Pathway in …
Our findings strongly suggest that PAF-AH catalytic subunits modulate the Wnt pathway in restricted areas of the developing cerebral cortex. We hypothesize that modulation of the Wnt …
PAF and EZH2 Induce Wnt/β-Catenin Signaling Hyperactivation
2013年10月24日 · Our studies reveal an unexpected role of PAF in regulating Wnt signaling and propose a regulatory mechanism of Wnt signaling during tumorigenesis. Strict regulation of …