p53 talks to PARP: the increasing complexity of p53-induced
2013年10月7日 · The p53 tumor suppressor is well known for its ability to trigger cell death by apoptosis or induce cellular senescence. p53 is also involved in a wide range of other...
Rapid recruitment of p53 to DNA damage sites directs DNA repair …
We report that endogenous p53 rapidly accumulates at DNA damage sites within 2 s of UVA microirradiation. The kinetics of p53 recruitment mimics those of known DNA damage …
p53 regulates a non-apoptotic death induced by ROS
2013年5月24日 · Here we identify a novel role for p53 in modulating PARP enzymatic activity to regulate necrotic cell death. In mouse embryonic fibroblasts, human colorectal and human …
Selective therapeutic strategy for p53-deficient cancer by ... - Nature
2021年7月12日 · PARP inhibitors olaparib and talazoparib enhanced DNA damage and cytotoxicity caused by deoxyuridine analogues in p53mt cells, while activating the p53−p21 …
PARP1 Is Required for ATM-Mediated p53 Activation and p53
2020年7月20日 · PARP1 and p53 are key players in maintaining genomic stability, but their interplay is still not fully understood. We investigated the impact of PARP1 knockout on the …
PARP-1 modifies the effectiveness of p53-mediated DNA …
2002年2月7日 · The tumour suppressor protein p53 plays a key role in the cell's decision to arrest the cell cycle or undergo apoptosis following a genotoxic insult. p53 is stabilized and activated …
Poly(ADP-ribose) polymerase inhibition enhances p53-dependent …
2011年12月1日 · Targeting DNA repair with poly (ADP-ribose) polymerase (PARP) inhibitors has shown a broad range of anti-tumor activity in patients with advanced malignancies with and …
文献解读|p53突变的肿瘤类器官对PARP抑制剂联合治疗具有协同 …
本研究通过乳腺癌和肺癌类器官药敏检测结果，发现p53突变的类器官对PARP抑制剂治疗具有协调作用，同时设计了一种诊断肽Cy5p53Tet，用于检测p53表达水平。在没有BRCA1/2基因突变 …
PNAS丨周祥团队揭示p53维护基因组稳定和诱导肿瘤化疗耐药的新 …
2025年3月12日 · 该研究团队此前还发现，在parp抑制剂的作用下，长链非编码rna rmrp会抑制p53蛋白充分活化，进而可能通过阻滞细胞周期、促进损伤修复等通路，使肿瘤细胞对parp抑 …
Poly(ADP-ribose) Polymerase-1 Is a Positive Regulator of the p53 ...
2003年5月23日 · These experiments reveal that inhibition of PARP-1 activity with IQ or with PARP-1 DBD overexpression suppresses the transactivation function of p53 and the ability of …
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