2005年10月15日 · A functional interaction between poly(ADP-ribose) polymerase-1 (PARP-1) and lamin B has recently been proposed by nuclear fractionation, crosslinking, and immunoprecipitation experiments. Here we use fluorescence microscopy to verify …

2005年7月28日 · A functional interaction between poly (ADP‐ribose) polymerase‐1 (PARP‐1) and lamin B has recently been proposed by nuclear fractionation, crosslinking, and immunoprecipitation experiments. Here we use fluorescence microscopy to verify …

2024年2月1日 · PARP1 rapidly binds DNA breaks, an event that triggers its catalytic activity, namely, the addition of long, branched, and negatively charged poly (ADP-ribose) (PAR) polymer chains (PARylation) onto itself and other proteins in the vicinity of breaks [10].

2017年7月5日 · Poly (ADP-ribose) polymerase 1 (PARP1) was the first member of the PARP family to be identified. The PARP family now comprises 18 members. PARP1 post-translationally modifies itself and a range...

PARP‐1 is found to be involved in a myriad of cellular events via conservation of genomic integrity, chromatin dynamics and transcriptional regulation. This article briefly focuses on its other equally important overlooked functions during growth, metabolic regulation, spermatogenesis, embryogenesis, epigenetics and differentiation.

2022年3月9日 · PARP1 plays important roles in DNA damage repair networks, including SSB repair, base excision repair (BER), nucleotide excision repair (NER), and DSB repair through both homologous recombination (HR) and nonhomologous end-joining (NHEJ) pathways (Audebert et al., 2004; Bryant et al., 2009; Caldecott et al., 1996; Ceccaldi et al., 2016; El-Khami...

2025年1月25日 · Poly (ADP-ribose) polymerase-1 (PARP-1) is the key enzyme among other PARPs for post-translational modification of DNA repair proteins. It has four functional domains for DNA-binding, automodification and enzymatic activity. PARP-1 participates in poly-ADP-ribosylation of itself or other proteins during DNA damage response.

Poly (ADP-ribose) polymerase 1 (PARP1, also known as ADPRT1) is a multifunctional human ADP-ribosyltransferase. It plays a role in multiple DNA repair pathways, including the base excision repair (BER), non-homologous end joining (NHEJ), homologous recombination (HR), and Okazaki-fragment processing pathways.

2005年10月15日 · After DNA damage and the associated activation of PARP-1, and during the subsequent entry into apoptosis, dramatic changes occur: a gradual release of the enzyme from the lamina, accompanied by...

2024年8月8日 · PARP1 is the most widely studied protein in this family and plays a well-defined role in the response to DNA damage, either by loosening chromatin at specific sites to promote DNA repair or by prompting cell death to maintain genomic integrity in …