The present review focuses on recent studies showing that PARs are critically involved in itch and sensitization of itch. PARs are expressed by diverse cell types including primary sensory …

Finally, several studies suggest that activation of PAR-2 can also elicit itch, either directly by activation of the receptor on sensory nerve fibers innervating the skin, or indirectly by …

2006年7月1日 · In contrast to the separated neuronal pathways, the results have revealed that a broad overlap exists between pain and itch processing in terms of mediators, mechanisms and …

2023年11月22日 · Pruriceptors are activated by V8 protease through proteinase-activated receptor 1 (PAR1). Targeting V8 or PAR1 abrogates itch and barrier damage, leading to …

2023年11月22日 · Protease-activated receptors (PARs) belong to the G protein-coupled receptor family and are activated upon protease cleavage of the extracellular domain. Importantly, …

The present review focuses on recent studies showing that PARs are critically involved in itch and sensitization of itch. PARs are expressed by diverse cell types including primary sensory …

The present review focuses on recent studies showing that PARs are critically involved in itch and sensiti-zation of itch. PARs are expressed by diverse cell types including primary sensory …

2015年4月11日 · Protease-activated receptors (PARs) have been implicated in a variety of physiological functions, as well as somatosensation and particularly itch and pain....

2013年5月1日 · In this review, we provide new insights into distinct molecular mechanisms of itch, especially nonhistaminergic itch signaling, mediated by Mas-related G protein-coupled …

2023年12月8日 · Emerging evidence clearly implicates TRP channels, Mrgprs, and PARs in a variety of itch-inducing mechanisms relevant to diseases which produce chronic itch. Since …