ELN-PAX5 interaction results in the decreased expression of LEF1, MB1, and BLNK, while PML-PAX5 is critical in the early stages of leukemia. PAX5 fusion genes prevent the transcription of …

We developed preclinical strategies to target PAX5 fusion genes. We identified 135 cases without recurrent genetic rearrangements. Among them, 59 patients (43·7%) had a Ph-like signature; …

2013年11月15日 · We have established an in vitro model in which wild-type murine pre-BI cells were transduced with the most recurrent PAX5 fusion gene, PAX5/ETV6. Gene expression …

2008年11月20日 · PAX5, a master regulator of B-cell development, was recently shown to be involved in several leukemia-associated rearrangements, which result in fusion genes …

2019年1月14日 · We show that p.Pro80Arg impairs B lymphoid development and promotes the development of B-ALL with biallelic Pax5 alteration in vivo. These results demonstrate the …

2014年2月7日 · Our report underlines the recurrent involvement of PAX5 in different fusion genes resulting either from t(7;9)(q11.2;p13) or der(9)t(7;9)(q11.2;p13), which cannot be …

We developed preclinical strategies to target PAX5 fusion genes. Findings: We identified 135 cases without recurrent genetic rearrangements. Among them, 59 patients (43·7%) had a Ph …

pax5 结构畸变是各种形式 b-all 中常见的重要遗传事件，包括框架内基因融合、3'缺失（pax5::zcchc7）和局灶外显子缺失。 OGM结合RNA-seq有助于破译病理PAX5结构异常。

2007年4月17日 · Here we review the experimental evidence implicating Pax5 in the transcriptional control of B cell commitment, development and function as well as in B cell tumorigenesis. …

PAX5 rearranged cases among the Ph-like subgroup of children with BCP-ALL diagnosed in Italy. We herewith tested ex vivo and in vivo the efficacy of the LCK inhibi-tor …