2023年11月2日 · Anatomical tracing reveals that PCs inhibit PBN neurons that make extensive monosynaptic connections to the amygdala, septum, basal forebrain, cingulate cortex, piriform cortex and the...

2023年8月4日 · Potentiation of excitatory synaptic transmission in the parabrachial nucleus (PBN) to central amygdala (CeA) pathway has been reported in rodent models of persistent pain.

2016年6月15日 · Here we identify cholecystokinin (CCK) and noradrenergic, dopamine β-hydroxylase (DBH)-expressing NTS neurons as two separate populations that directly excite CGRP PBN neurons. When these NTS...

The parabrachial nucleus (PBN), which is located in the pons and dissected by one of the major cerebellar output tracks, is known to relay sensory information (visceral malaise, taste, temperature, pain, itch) to forebrain structures including the thalamus, hypothalamus and extended amygdala.

2022年2月15日 · Activation of the PBN-PVT pathway induces robust behaviors associated with negative affective states without affecting nociceptive behaviors. Inhibition of the PBN-PVT pathway reduces aversion-like and fear-like behaviors.

2022年11月1日 · The parabrachial nucleus (PBN) is a major hub that receives sensory information from both internal and external environments. Specific populations of PBN neurons are involved in behaviors including food and water intake, nociceptive responses, breathing regulation, as well as learning and responding appropriately to threatening stimuli.

In this study, we uncovered the lateralized function of the PBN in driving neuropathic pain, which depends on NK1R activation in the right-sided PBN. We also demonstrated that peripheral nerve injury induces short-term facilitation in the spino-parabrachial pathways targeting the right-sided PBN, regardless of the injury side.

2016年6月1日 · Using c-Fos immunohistochemistry as a marker of neural activity, we first show a selective increase in active neurons in the PBN during passive emergence from isoflurane anesthesia. We then electrically stimulated the PBN to assess whether it is sufficient to induce reanimation from isoflurane general anesthesia.

2022年1月1日 · In this study, a chronic neuropathic pain (CNP) model was established using partial sciatic nerve ligation (PSNL) in mice to observe the effects of direct suppression of the parabrachial nucleus (PBN) on CNP and CNP-related behaviors in mice.

2006年5月2日 · The present results showed that the loss of Fos-mediated signaling in the PBN during the conditioning weakened the acquisition of CTA, resulting in the attenuated retention of CTA. This finding suggests that Fos-mediated gene transcription in the PBN plays an important role in cellular plasticity underlying the acquisition of taste memory.