The possibility of alleviating chronic neuropathic pain and …
2022年1月1日 · In this study, a chronic neuropathic pain (CNP) model was established using partial sciatic nerve ligation (PSNL) in mice to observe the effects of direct suppression of the …
The Parabrachial Nucleus Directly Channels Spinal Nociceptive …
2020年9月9日 · Here, we report that the PBN directly relays nociceptive signals from the spinal cord to the intralaminar thalamic nuclei (ILN). We demonstrate that the spinal cord connects …
The parabrachial to central amygdala pathway is critical to injury ...
2023年8月4日 · Potentiation of excitatory synaptic transmission in the parabrachial nucleus (PBN) to central amygdala (CeA) pathway has been reported in rodent models of persistent pain.
Parabrachial nucleus circuit governs neuropathic pain-like …
2020年11月25日 · Here we report that neuropathic pain-like hypersensitivity induced by common peroneal nerve (CPN) ligation increases nociceptive stimulation-induced responses in …
A Purkinje cell to parabrachial nucleus pathway enables broad ...
2023年11月2日 · To determine more definitively whether PBN neurons are inhibited directly by PCs, we characterized the PC–PBN synapse in acute coronal PBN brain slices using PCP2 …
PBN-PVT projections modulate negative affective states in mice
2022年2月15日 · The parabrachial nucleus (PBN) and thalamic paraventricular nucleus (PVT) are critical for modulating affective states in mice. However, the functional roles of PBN-PVT …
Parabrachial Hyperexcitability In A Mouse Model Of Neuropathic …
2023年4月1日 · Data from in vivo and histological studies have shown that PBN neurons are largely responsive to noxious stimuli and become hyperexcitable following induction of pain. …
Spared nerve injury differentially alters parabrachial monosynaptic ...
The spared nerve injury model of neuropathic pain differentially altered PBn monosynaptic excitatory input to CeA neurons based on molecular identity and topographical location within …
Divergent changes in PBN excitability in a mouse model of
2023年10月11日 · Using ex vivo slice electrophysiology and two mouse models of neuropathic pain, sciatic cuff and chronic constriction of the infraorbital nerve (CCI-ION), we find that …
Divergent Changes in PBN Excitability in a Mouse Model of
Using ex vivo slice electrophysiology and two mouse models of neuropathic pain, sciatic cuff and chronic constriction of the infraorbital nerve (CCI-ION), we find that changes in the firing …