PBRM1 Gene - GeneCards | PB1 Protein | PB1 Antibody
2024年12月25日 · PBRM1 (Polybromo 1) is a Protein Coding gene. Diseases associated with PBRM1 include Clear Cell Renal Cell Carcinoma and Renal Cell Carcinoma, Nonpapillary. Among its related pathways are Gene expression (Transcription) and Chromatin organization. Gene Ontology (GO) annotations related to this gene include chromatin binding.
PBRM1 - Wikipedia
Protein polybromo-1 (PB1) also known as BRG1-associated factor 180 (BAF180) is a protein that in humans is encoded by the PBRM1 gene. [5][6][7]
PBRM1 mutation as a predictive biomarker for immunotherapy in …
PBRM1 encodes the BAF180 protein, which is important in chromatin remodeling (Lu and Allis, 2017; Zhou et al., 2020). PBRM1 genes had approximately 5% mutational frequency in cancer, while with high frequency of about 20%–40% in ccRCC(15).
PBRM1 mutation and preliminary response to immune checkpoint …
2020年3月16日 · Polybromo-1 (PBRM1) gene is a promising biomarker for immunotherapy in clear cell renal cell carcinoma. But to our knowledge, the frequency and clinical relevance of PBRM1...
PBRM1 polybromo 1 [Homo sapiens (human)] - Gene - NCBI
2025年1月4日 · Title: PBRM1, SETD2 and BAP1 - the trinity of 3p in clear cell renal cell carcinoma. Nonsmall cell lung cancer carrying PBRM1 mutation suggests an immunologically cold phenotype leading to immunotherapy failure even with high TMB.
PBRM1 loss defines a nonimmunogenic tumor phenotype …
2020年5月1日 · In this study, we found that PBRM1 loss reduced IFNγ-STAT1 signaling in murine and human RCC cell lines, respectively, in a SWI/SNF complex dependent manner. PBRM1 inactivation was associated...
Nat Cell Biol：揭示特殊基因的缺失诱发人类肾癌发生的分子机制
2023年8月7日 · pbrm1的失活是一类由改变细胞中dna结构所引起的遗传改变，科学家们一直在寻找方法来靶向作用并治疗这些改变从而预防癌症发生；而本文研究已经 ...
PBRM1, SETD2 and BAP1 — the trinity of 3p in clear cell ... - Nature
2022年10月17日 · Results from genomic studies have shown that co-deletions of VHL with one (or more) of three genes encoding proteins involved in chromatin modification and remodelling, polybromo-1 gene (PBRM1),...
PBRM1 Regulates the Expression of Genes Involved in Metabolism ... - PubMed
2016年4月21日 · PBRM1 re-expression led to upregulation of genes involved in cellular adhesion, carbohydrate metabolism, apoptotic process and response to hypoxia, and a downregulation of genes involved in different stages of cell division.
多溴联苯 1（PBRM1）基因 | MCE - MCE-生物活性分子大师
该基因座编码 ATP 依赖性染色质重塑复合物的一个亚基。 编码的蛋白质已被确定为核激素受体配体依赖性转录激活所必需的复合物的组成部分。 该位点的突变与原发性透明细胞肾细胞癌有关。 [RefSeq 提供，2012 年 2 月] This locus encodes a subunit of ATP-dependent chromatin-remodeling complexes.