First, we describe the protein nature of the PcG body and the gene silencing factory model. Second, we review the target genes of Polycomb-mediated silencing and discuss their essentiality for the structural nature of the PcG body.

2018年1月1日 · Polycomb bodies are foci of polycomb group (PcG) proteins that have been observed within the nucleus of Drosophila and mammalian cells. Their size and number varies within different cell types, and their distribution is developmentally regulated.

近日，来自牛津大学的 Neil P. Blackledge 和 Robert J. Klose 在 Nature Reviews Molecular Cell Biology 上发表了题为 The molecular principles of gene regulation by Polycomb repressive complexes 的综述， 详细讨论了PRC在染色质层面上调控哺乳动物基因表达的分子机制，并展望了未来PRC与人类健康与疾病相关的研究。 PRC是什么？ Polycomb 基因最初在黑腹果蝇中发现，它在果蝇中能够抑制同源 (Hox) 基因。 Polycomb在果蝇中压缩DNA，通过表观遗传修饰控制基 …

2012年4月1日 · Polycomb group (PcG) proteins are concentrated in nuclear foci called PcG bodies. Although some of these foci are due to the tendency of PcG binding sites in the genome to occur in linear clusters, distant PcG sites can contact one another and in some cases congregate in the same PcG body when they are repressed.

Polycomb group (PcG) proteins of the Polycomb repressive complex 1 (PRC1) are found to be diffusely distributed in nuclei of cells from various species. However they can also be localized in intensely fluorescent foci, whether imaged using GFP …

Polycomb group (PcG) proteins of the Polycomb repressive complex 1 (PRC1) are found to be diffusely distributed in nuclei of cells from various species. However they can also be localized in intensely fluorescent foci, whether imaged using GFP fusions to proteins of PRC1 complex, or by conventional immunofluorescence microscopy.

PcG bodies are conspicuous in human osteosarcoma U-2 OS cells where their relative sizes differ from 0.2 to 1.5 μm and their number varies between six and fourteen per nucleus.

2013年8月12日 · A Polycomb (PcG) body is an orphan nuclear subcompartment characterised by accumulations of Polycomb repressive complex 1 (PRC1) proteins. However, seemingly contradictory reports have appeared that describe the PcG bodies either as protein-based bodies in the interchromatin compartment or chromatin domains.

2011年5月1日 · Polycomb group (PcG) proteins of the Polycomb repressive complex 1 (PRC1) are found to be diffusely distributed in nuclei of cells from various species. However they can also be localized in intensely fluorescent foci, whether imaged using GFP fusions to proteins of PRC1 complex, or by conventional immunofluorescence microscopy.

Polycomb group (PcG) 蛋白是一组通过染色质修饰调控靶基因的转录抑制子, 从生化和功能上它可以分成两个主要的核心蛋白复合体PRC1 (Polycomb repressive complex 1)和PRC2 (Polycomb repressive complex 2)。研究发现PcG蛋白不仅控制个体正确的发育模式, 而且与细胞的增殖、分化和肿瘤发生有关。文章就PcG蛋白的组成、作用机制及功能进行综述, 并对PcG未来的研究方向进行展望。 关键词: 干细胞, 染色质修饰, 转录抑制, PcG蛋白. Abstract: