Phosphoenolpyruvate carboxykinase 1 (soluble), also known as PCK1, is an enzyme which in humans is encoded by the PCK1 gene. [5][6] This enzyme is a main control point for the …

2024年12月25日 · PCK1 (Phosphoenolpyruvate Carboxykinase 1) is a Protein Coding gene. Diseases associated with PCK1 include Phosphoenolpyruvate Carboxykinase Deficiency, …

We show here that this enzyme is crucial for the maintenance of normal tubular physiology, lactate, and glucose homeostasis. PCK1 is a regulator of acid-base balance and …

2020年4月8日 · Here we show that activated AKT in human hepatocellular carcinoma (HCC) cells phosphorylates cytosolic phosphoenolpyruvate carboxykinase 1 (PCK1), the rate-limiting …

2023年3月14日 · Phosphoenolpyruvate carboxykinase 1 (PCK1) is the first rate-limiting enzyme in gluconeogenesis and converts oxaloacetate to phosphoenolpyruvate in the cytoplasm 5....

2021年10月7日 · Phosphoenolpyruvate carboxykinase 1 (PCK1) is the rate-limiting enzyme of gluconeogenesis. The current study tested the expression and potential functions of PCK1 in …

Mechanistically, fasting or caloric restriction of mice leads to neddylation of phosphoenolpyruvate carboxykinase 1 (PCK1) at three lysine residues—K278, K342, and K387. We find that …

PCK1 regulates neuroendocrine differentiation in a positive feedback loop of LIF/ZBTB46 signalling in castration-resistant prostate cancer. Gluconeogenic enzyme PCK1 deficiency …

PCK1 is widely involved in the reprogramming of glucose and lipid metabolism in cancer. PCK1 plays non-metabolic functions, such as angiogenesis, epigenetic modification, and immune …

Phosphoenolpyruvate carboxykinase 1 (PCK1) is the rate-limiting enzyme of gluconeogenesis. The current study tested the expression and potential functions of PCK1 in pancreatic cancer. …