2019年1月7日 · pCO2 gap is a surrogate for cardiac output; pCO2 gap = PcvCO2 - PaCO2; pCO2 gap >6 mmHg suggests a persistent shock state that may be amenable to fluid resuscitation +/- intrope support; a “ScvO2-cvaCO2gap-guided protocol” has been proposed to guide the management of septic shock

2021年8月31日 · In this chapter, we present the physiological and pathophysiological determinants of the Pv-aCO 2 gap and review its implications in the clinical assessment of circulatory shock. Under aerobic conditions, CO 2 is produced at the mitochondrial level as a by-product of substrate oxidation (pyruvate and citric acid cycle intermediates) (Fig. 1).

2023年10月24日 · 二氧化碳分压的静脉-动脉差 (Pv-aCO 2 GAP）越来越被认为是评估组织灌注的可靠工具和循环休克期间不良结果的标志，因此它应该成为综合临床评估的一部分 。

The PCO2 gap is an important hemodynamic variable in the management of sepsis-induced circulatory failure. The PCO2 gap can be a marker of the adequacy of the cardiac output status in severe sepsis. A high PCO2 gap value (>0.8 kPa) can identify situations in which increasing CO can be attempted with fluid resuscitation in severe sepsis.

2021年8月31日 · 3 Unit of Pathophysiology, Faculty of Biology and Medicine, University of Lausanne, 1011, Lausanne, Switzerland. This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2021. Other selected articles can be found online at https://www.biomedcentral.com/collections/annualupdate2021 .

2021年10月2日 · 二氧化碳的溶解，根据亨利气体溶解度定律：Vgas=Sgas× (Pgas/Patm)，溶解的二氧化碳分数与二氧化碳分压（PCO2）为守恒关系，其中Vgas是溶解气体的体积 (单位 ml/ml)，Sgas是气体溶解的亨利常数（37°C时，CO2的亨利常数为0.52ml/ml），Patm为大气压。 因此，在PaCO2为40 mmHg（在海平面，37°C的状态下）的动脉血中，溶解的CO2= [0.52×（40/760）]=27 ml/l，约为总二氧化碳的5%（注意，以mmol/l为单位时，CO2的亨利常 …

2023年12月18日 · CO2 溶解分数，与 CO2 分压 (PCO2) 处于平衡状态，根据气体溶解度亨利定律：Vgas=Sgas× (Pgas/Patm)，其中 Vgas 为溶解气体的体积（ml/ ml)，Sgas 是气体溶解度的亨利常数（CO2 在 37 °C 时为 0.52 ml/ml），而 Patm 是大气压。 因此，在 PaCO2 为 40 mmHg（海平面，37 °C）的动脉血中，溶解的 CO2= [0.52× (40/760)]=27 ml/L，约占总 CO2 的 5%（请注意，以 mmol/L 为单位，CO2 的亨利常数 = 0.03 mmol/L/mmHg；从 mmol 到 ml CO2 的转换系 …

The PCO 2 gap is difference between partial pressure of CO 2 in venous blood (PvCO 2) and arterial blood (PaCO 2). PCO 2 gap is considered to be a marker of relationship between cardiac output (CO) to global metabolic demand, i.e., a marker of adequacy of venous blood flow to eliminate CO 2 produced by peripheral tissues.

The mixed venous blood O 2 saturation (SvO 2) and the difference between mixed venous and arterial blood carbon dioxide (CO 2) pressures (PCO 2 gap) have been proposed to assess the adequacy of cardiac output to metabolic conditions and thus to serve to evaluate the need to increase cardiac output.

We found that a persistently high PCO 2 gap at 6 and 12 h following resuscitation in patients with shock of various etiologies, was associated with increased mortality, need for RRT and increased ICU LOS. High PCO 2 gap had a moderate discriminative ability to predict mortality.