Purkinje cell protein 4 is a protein that in humans is encoded by the PCP4 gene. [5] [6] [7] Also known as PEP-19, PCP4 is a 7.6 kDa protein with an IQ-motif that binds to calmodulin (CaM). [8] PCP4 is abundant in Purkinje cells of the cerebellum, and plays an …

2024年12月25日 · PCP4 (Purkinje Cell Protein 4) is a Protein Coding gene. Diseases associated with PCP4 include Leiomyoma and Autoimmune Atherosclerosis. Gene Ontology (GO) annotations related to this gene include calmodulin binding. An important paralog of this gene is PCP4L1. Functions as a modulator of calcium-binding by calmodulin.

PCP4 is a regulator of aldosterone production in normal, hyperplastic, and neoplastic human adrenocortical cells. This study demonstrate that Pcp4 overexpression extended these effects later in development by modulating genes in line with the maturation of neurons in the cerebellum.

Enables Calmodulin binding activity. Predicted to be involved in several processes, including Calmodulin dependent kinase signaling pathway; negative regulation of protein kinase activity; and positive regulation of dopamine secretion. Predicted to be located in axon and neurofilament. Predicted to be part of protein-containing complex.

Purkinje cell protein 4 (PCP4), also called brain-specific polypeptide 19 (PEP19), is a neurospecific, small calmodulin-binding protein that binds both calcium-free and calcium-binding calmodulin to regulate the calmodulin-mediated signal.

Gene target information for PCP-4. Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

We report the cloning of a novel mouse gene (Pcp4l1) that encodes a polypeptide with significant sequence similarity to the Purkinje cell protein 4 gene (Pcp4) and describe its expression pattern during mouse development [3]. Pcp4l1, a novel gene encoding a Pcp4 -like polypeptide, is expressed in specific domains of the developing brain [3].

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PCP-4 (Purkinje cell protein 4), also known as PEP-19, is a calmodulin (CaM) regulatory protein that is highly expressed in neuronal cells. Through its IQ motif, PCP-4 mediates both the calcium-dependent binding properties of CaM and the rates of association and dissociation of calcium from the C-terminal domain of CaM.

PCP-4, also known as Purkinje Cell Protein 4, plays a critical role in the regulation of neuronal signaling and synaptic plasticity, making it essential for proper brain function. Its involvement in the modulation of ion channels and neurotransmitter receptors highlights its significance in neurodevelopmental processes and potential ...