2022年9月21日 · RESULTS In this study, we used artificial intelligence (AI)-based prediction to generate an exten-sive repertoire of structural models of human NUPs and their subcomplexes. The resulting models cover various domains and interfaces that so far remained structurally uncharac-terized.

Biological Unit for 7R5J: 808-meric; determined by author and by software (PISA)

Fitted models: 7r5j Deposition Authors: Mosalaganti S , Obarska-Kosinska A AI-based structure prediction empowers integrative structural analysis of human nuclear pores

2022年9月21日 · 7r5j overview; Citations; Structure analysis; Function and Biology; Ligands and Environments; Experiments and Validation; View

Here, we report that (S)-ACE-OH, a metabolite of the antipsychotic drug acepromazine, acts as a molecular glue to induce an interaction between the E3 ubiquitin ligase TRIM21 and the nucleoporin NUP98, leading to the degradation of nuclear pore proteins and disruption of nucleocytoplasmic trafficking.

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2022年2月10日 · PDB Entry - 7R5J (Status - Released) Summary information: Title: Human nuclear pore complex (dilated) PDB DOI: https://doi.org/10.2210/pdb7r5j/pdb. Primary publication DOI: https://doi.org/10.1126/science.abm9506

AladinE3 SUMO-protein ligase RanBP2Nuclear pore complex protein Nup107Nuclear pore complex protein Nup133Nuclear pore complex protein Nup155Nuclear pore complex protein Nup160

PDB Format (Header) Download Files . FASTA Sequence; PDBx/mmCIF Format; PDBx/mmCIF Format (gz) BinaryCIF Format (gz) PDB Format ... Validation (CIF - gz) Biological Assembly 1 (CIF - gz) Data API . 7R5J. Human nuclear pore complex (dilated) ELECTRON MICROSCOPY. Sample; Human nuclear pore complex from HEK cells: Specimen Preparation; Sample ...

7r5j overview; Citations; Structure analysis; Function and Biology; Ligands and Environments; Experiments and Validation; Downloads