RCSB Protein Data Bank (RCSB PDB) enables breakthroughs in science and education by providing access and tools for exploration, visualization, and analysis of: These data can be …

2024年9月23日 · Using AK-068 and cereblon ligands, we discovered AK-1690 as the first, potent and selective PROTAC STAT6 degrader. AK-1690 effectively induces degradation of STAT6 …

It is commonly referred to as PKB, or by both names as "Akt/PKB". The serine-threonine protein kinase AKT1 is catalytically inactive in serum-starved primary and immortalized fibroblasts. …

2023年4月10日 · PDBsum is a pictorial database that provides an at-a-glance overview of the contents of each 3D structure deposited in the Protein Data Bank (PDB). It shows the …

2016年3月9日 · The Protein Data Bank (PDB)--the single global repository of experimentally determined 3D structures of biological macromolecules and their complexes--was established …

2024年4月23日 · Using AK-068 and cereblon ligands, we discovered AK-1690 as the first, potent and selective PROTAC STAT6 degrader. AK-1690 effectively induces degradation of STAT6 …

2023年2月2日 · Here we report the development of AK-2292 as a first, potent and selective small-molecule degrader of both STAT5A and STAT5B isoforms. AK-2292 induces degradation of …

蛋白质资料库（Protein Data Bank，简称PDB）是一个专门收录蛋白质及核酸的三维结构资料的数据库。由Worldwide Protein Data Bank监管。PDB可以经由网络免费访问，是结构生物学研究 …

In the apo/ unligated structure, the ATP-bind and AMP-bind domains assume open conformations (Fig. 2 a ; PDB code 4AKE) (41). A closed conformation (Fig. 2 b ), crystallized with the …

Using AK-068 and cereblon ligands, we discovered AK-1690 as the first, potent and selective PROTAC STAT6 degrader. AK-1690 efectively induces degradation of STAT6 protein in cells …