Phosphodiesterase 1, PDE1, EC 3.1.4.1, systematic name oligonucleotide 5 ′-nucleotidohydrolase) is a phosphodiesterase enzyme also known as calcium- and calmodulin …

PDE1 is a dual substrate (cAMP and cGMP) diesterase and a promising target for the treatment of heart disease, cancer, neurological disorder and other endocrine abnormalities.

2024年12月25日 · PDE1A (Phosphodiesterase 1A) is a Protein Coding gene. Diseases associated with PDE1A include Fraser Syndrome 1 and Nephrolithiasis. Among its related …

As a Class 1 phosphodiesterase, PDE1 hydrolyzes the 3' bond of 3'-5'-cyclic nucleotides, cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). Here, we …

2022年10月7日 · 磷酸二酯酶 1 （ phosphodiesterases 1, PDE1 ）是磷酸二酯酶家族的成员之一，可同时水解第二信使 cAMP 和 cGMP ，高表达于脑组织。 PDE 蛋白介导的相关信号通路参 …

PDE1 is a group of enzymes that require both calcium and calmodulin for their activity. They are encoded by three genes in humans and are involved in the degradation of cyclic nucleotides, …

环核苷酸磷酸二酯酶 (PDE) 通过将 cAMP 和/或 cGMP 水解成各自的核苷 5-主要单磷酸来调节细胞内环核苷酸浓度，从而在信号转导中发挥作用。 PDE1 家族的成员，例如 PDE1A，是 CA …

PDE1 (phosphodiesterase1) is a phosphodiesterase enzyme also known as calcium - and calmodulin -dependent phosphodiesterase. It is one of the 11 families of phosphodiesterase …

Phosphodiesterase(PDE) 是一种可以催化环核苷酸3 '环磷酸键水解的酶，常用于生化研究。Phosphodiesterase 可作为第二信使分子 cAMP 和 cGMP 介导的信号转导的重要调节因子。根 …

Phosphodiesterase-1 (PDE1) is a versatile enzyme that has surprisingly received considerable attention as a possible therapeutic target in Alzheimer’s disease (AD) because it maintains the …