PDE3 is a phosphodiesterase. The PDEs belong to at least eleven related gene families, which are different in their primary structure, substrate affinity, responses to effectors, and regulation …

In this review, we will discuss some general information of PDEs and then focus on PDE3 gene family, including the molecular biology, structure, function and potential as therapeutic targets. …

Inhibitors of PDE3, a family of dual-specificity cyclic nucleotide phosphodiesterases, are used clinically to increase cardiac contractility by raising intracellular cAMP content in cardiac …

2007年3月2日 · This review highlights the role of cAMP-hydrolyzing PDE3 in the cardiac muscle, the potential cellular and molecular mechanisms of adverse cardiac effects of chronic PDE3 …

2005年5月2日 · Multiple cAMP-hydrolyzing phosphodiesterases (PDEs), such as PDE3 and PDE4, coexist in cardiomyocytes and elicit differential temporal/spatial regulation of cAMP …

The data suggest that PDE3A is the main subtype of PDE3 expressed in platelets and cardiac ventricular myocytes, and is responsible for the functional changes caused by PDE3 inhibition. …

PDE3A and PDE3B are the subfamily genes of PDE3, which shows high affinity for both cAMP and cGMP. A low Vmax value for cGMP compared with that for cAMP lets cGMP function as a …

2021年10月27日 · In this work, we report the high-resolution cryo-electron microscopy structure of PDE3A-SLFN12 complexes isolated from cultured HeLa cells pre-treated with either …

2016年3月2日 · Zhi-Wei Mao and Qiao-Ling Li contributed equally to this work. The classical phosphodiesterase 3A (PDE3A) inhibitors provide relaxation of the vasculature system via …

2022年9月1日 · PDE3 controls cardiac excitation–contraction coupling by modulating cAMP–PKA regulation of ICa,L (refs. 133, 157, 158, 159, 160) and Ca 2+ uptake in the sarcoplasmic …