DC591017, a phosphodiesterase-4 (PDE4) inhibitor with robust …
Consistently, DC591017 decreased expression of PDE4 isoforms and subsequently regulated PKA-CREB and NF-κB signaling. In brief, our study brought out a patent PDE4 inhibitor with …
Phosphodiesterase 4 inhibition after retrieval switches the ... - Nature
2023年11月21日 · Phosphodiesterase 4 (PDE4), an enzyme expressed in the dorsal hippocampus (DH), hydrolyzes the cAMP, limiting the PKA-induced CREB phosphorylation …
Targeting PDE4 as a promising therapeutic strategy in chronic ...
2022年1月1日 · Therapeutically, inhibition of PDE4 by apremilast modulated cAMP-predominant protein kinase A (PKA)–cAMP-response element binding protein (CREB) signaling and …
DC591017，一种磷酸二酯酶4（PDE4）抑制剂，通过调节PKA-CREB …
在多种炎症性疾病中，pde4的抑制被认为是一种有效的治疗策略。 这项研究旨在评估PDE4抑制剂DC591017在体外和体内的抗炎作用。 将小鼠RAW264.7细胞，BMDM，BMDC和人NHEK …
Research progress on phosphodiesterase 4 inhibitors in central …
2024年6月6日 · PDE4 inhibitors have long-term potentiation effect, which can enhance phosphorylation of cAMP response element binding protein (CREB) and upregulate …
cAMP_PKA_CREB信号通路及相关调控蛋白PDE_4和ERK对学习记忆 …
磷酸二酯酶 4 （ Phosphodiesterase 4，PDE-4） 是 cAMP 特异性水解酶，PDE 能催化环腺苷酸的 3'，5'-磷酸二酯键的水解，生成无 活性的 5'-核苷单磷酸酯，使 cAMP 水平下降，进而可 …
PDE4 inhibitor upregulates PTH-induced osteoclast formation via …
2010年1月4日 · Two CRE sites in the COX-2 promoter were required for the increase in COX-2 transcription by PDE4 inhibitor, and the expression of a dominant-negative form of CREB …
Neuroprotective Effects of Cilomilast and Chlorogenic Acid Against ...
2 天之前 · PKA, CREB, BDNF and PDE4 were selected as central proteins to create separate networks, followed by a merged network to predict other molecular target proteins and …
Redox Biol 华中科技大学同济医学院付琴团队揭示靶向抑制磷酸二 …
2025年3月3日 · 首先，研究发现异丙肾上腺素(iso)诱导的心力衰竭小鼠心脏pde4d表达水平显著上调，而pde4b表达水平没有改变，同时pde4活性增加，而camp水平及pka底物受磷蛋白plb …
Enforced activation of the CREB/KDM2B axis prevents ... - Cell Press
2024年12月24日 · Alcohol exposure during peri-implantation delays embryonic development. Liu et al. show that acetaldehyde-induced CREB inactivation reduces KDM2BLF expression, …