PDE4 inhibitors roflumilast and rolipram augment PGE2 ... - PubMed
PDE4 inhibitors together with TGF-beta1 resulted in augmented PGE(2) production together with increased expression of COX mRNA and protein. The present study supports the concept that …
Prostaglandin E2 (PGE2) and Roflumilast Involvement in IPF …
2023年8月3日 · PDE4 inhibitors, such as Roflumilast, prevent the breakdown of cAMP, while TGFβ modulates cAMP by altering the metabolism of PGE2. The effect of PDE4 inhibitors …
Specificity and Mechanisms for Induction of PDE4 Up-Regulation by PGE2 …
2016年4月1日 · Prostaglandin E2 (PGE2) is an important modulator of the fibrotic changes that occur in pulmonary fibrosis and COPD. It is important to understand the mechanisms that …
The Complexity and Multiplicity of the Specific cAMP …
Furthermore, it was shown that PDE4 inhibitor enhances PGE2-induced growth arrest of osteoclast formation. It has been found that the PDE4 inhibitor in one way promotes the …
Phosphodiesterase 4A confers resistance to PGE2 ... - EMBO reports
2021年1月22日 · The solid tumor microenvironment is characterized by the presence of immunosuppressive factors, including prostaglandin E2 (PGE2), that limit NK cell persistence. …
Keynote review: Phosphodiesterase-4 as a therapeutic target
2005年11月15日 · Here, we delineate the range of PDE4 isoforms, their role in signaling, their structural biology and related preclinical and clinical pharmacology. Cyclic nucleotide …
Prostaglandin E2 alleviates inflammatory response and lung injury ...
2025年3月14日 · To investigate the potential role of cAMP in PGE2's anti-inflammatory activity, we employed the PDE4 inhibitor Roflumilast to enhance intracellular cAMP levels. Our findings …
PDE4 inhibitor suppresses PGE2-induced osteoclast formation ... - PubMed
We investigated the effects of phosphodiesterase 3 (PDE3) and PDE4 inhibitors, which are cAMP degrading enzymes, on prostaglandin E2 (PGE2)-induced osteoclast formation. A PDE4 …
用于疾病治疗的 PDE4 抑制剂：进展和未来展望。,Future …
2023年7月20日 · 作为信号转导的关键调节因子，pde4 在多种疾病中显示出有希望的药理学靶点，其抑制剂已被用作治疗策略。 本文全面总结了近几年PDE4抑制剂的发展情况，以及多 …
PGE2 Desensitizes β-Agonist Effect on Human Lung Fibroblast …
2013年10月8日 · In the current study, we investigated the effect of a long-acting β -agonist (salmeterol) and a phosphodiesterase 4 (PDE4) inhibitor (cilomilast) on human lung fibroblast …