In this study, the expression of PDE4 subtypes in primary microglial cells was assayed. Primary microglial cells were then transfected with specific small interfering RNA (siRNA) against each …

2016年10月6日 · In this study, the expression of PDE4 subtypes in primary microglial cells was assayed. Primary microglial cells were then transfected with specific small interfering RNA …

2015年7月10日 · Phosphodiesterase 4 (PDE4) has four isoforms (PDE4A-D) with at least 25 splice variants. PDE4 subtype nonselective inhibitors produce potent antidepressant-like and …

2011年1月5日 · Phosphodiesterase-4 (PDE4) plays an important role in mediating memory via the control of intracellular cAMP signaling; inhibition of PDE4 enhances memory. However, …

2013年4月9日 · In the present study, we identified PDE4B as a key negative regulator for CYLD via selective activation of c-jun N-terminal kinase 2 (JNK2), but not JNK1, and inhibition of …

Using quantitative PCR, expression of mRNA for PDE4A-D was found to be successfully reduced after transfection of U937 cells with small interfering RNA (siRNA) specifi c for each of the …

In the present study, we rectify this by providing the crystal structures of the catalytic domains of PDE4A, PDE4B and PDE4D in complex with the PDE4 inhibitor NVP {4- [8- (3-nitrophenyl)- …

Phosphodiesterase-4 (PDE4) inhibitors enhance memory, increase hippocampal neurogenesis, and reverse amyloid-β (Aβ)-induced memory deficits. Here, we examined whether long-form …

2024年8月25日 · Nerandomilast (BI 1015550), a preferential PDE4B inhibitor, improved bleomycin-induced fibrotic changes in a mouse model. Nerandomilast showed acceptable …

2015年4月28日 · PDE4 subtypes in microglial cells and the specific contri-bution of each subtype to inflammation remain unclear. In this study, the expression of PDE4 subtypes in primary …