cAMP-specific 3',5'-cyclic phosphodiesterase 4B is an enzyme that in humans is encoded by the PDE4B gene. [5] This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic …

2024年12月25日 · PDE4B (Phosphodiesterase 4B) is a Protein Coding gene. Diseases associated with PDE4B include Autism Spectrum Disorder and Ocular Hypotension. Among its …

该基因是 IV 型环磷酸二酯酶 (cAMP) 特异性环核苷酸磷酸二酯酶 (PDE) 家族的成员。 编码的蛋白质调节环核苷酸的细胞浓度，从而在信号转导中发挥作用。 这种蛋白质的活性改变与精神分 …

2020年5月19日 · However, we evaluate the evidence, which suggests the activity from a sub-family of the PDE4 family, namely PDE4B, underpins a range of important functions in the …

2024年3月23日 · Meta-analysis of genome-wide association study data has implicated PDE4B in the pathogenesis of Alzheimer’s disease (AD), the leading cause of senile dementia. PDE4B …

2022年10月5日 · Accumulating evidence suggests that PDE4B plays an important role in the pathogenesis and clinical manifestations of cancer, including proliferation, migration, and drug …

PDE4B expression was reduced in advanced prostate cancer and PDE4B knockdown promoted castration-resistant growth of LNCaP cells. The reported anti-inflammatory activity of bresol …

2013年4月9日 · Here, we show that inhibition of phosphodiesterase 4B (PDE4B) markedly enhances upregulation of CYLD expression in response to bacteria, thereby suggesting that …

2022年8月19日 · PDE4B blockade increased flow-mediated vasodilatation and promoted endothelium-dependent dilatation of coronary arteries in a PKA- and nitric oxide-dependent …

PDE4B may be characterized as a secondary PRP due to modulation of cAMP levels that promote the process through initial to late stage. As such PDE4B would function to modulate …