
Platelet-derived growth factor - Wikipedia
Platelet-derived growth factor is a dimeric glycoprotein that can be composed of two A subunits (PDGF-AA), two B subunits (PDGF-BB), or one of each (PDGF-AB). PDGF [1][2] is a potent mitogen for cells of mesenchymal origin, including fibroblasts, smooth muscle cells and glial cells.
什么是血小板衍生因子A(PDGF-AA? - 知乎
pdgf-aa的功能主要是促进细胞的增殖、分化和迁移,参与创伤修复、组织再生和造血等生理过程。 对于pdgf-aa的检测,可以通过生物学实验和免疫学实验等方法进行。
血小板源性生长因子 - 百度百科
血小板源性生长因子(platelet-derived growth factor,PDGF)是一种可刺激结缔组织增生的常见肽类调节因子,由骨髓巨噬细胞合成,贮存于血小板Q颗粒中。 PDGF是碱性糖蛋白,分子量为28~35kD,是由两亚基(A链和B链)通过二硫键结合而成的两条多肽链的二聚体。
血小板衍生生長因子 - 維基百科,自由的百科全書
血小板衍生生長因子(Platelet-derived growth factor,PDGF)為一種生長因子,可以調控細胞的生長和分化,且在血管新生上扮演重要角色。未控制的血管新生常常導致癌症。
血小板衍生生长因子(PDGF)生物学特性及医学领域的研究进展
血小板衍生生长因子 (Platelet-Derived Growth Factor, PDGF )是一类多功能的生长因子,广泛存在于生物体内。它们参与并调控了细胞增殖、迁移、分化以及血管生成等多个生物学过程,对创伤修复、组织再生以及血管疾病的治疗具有重要意义。
Platelet-derived growth factors and their receptors: structural and ...
Platelet-Derived Growth Factors (PDGFs) are a family of four cystine-knot-type growth factors (PDGF-A, -B, -C and -D) which control the growth of connective tissue cells such as fibroblasts and smooth muscle cells [1, 2].
重组Human PDGF-AA蛋白 (CHO-expressed) 人血小板衍生生长因子-AA (PDGF-AA …
PDGF是二硫键连接的二聚体,由两条12.0-13.5kDa的多肽链组成,命名为PDGF-A和PDGF-B。 三种天然存在的PDGF-AA、PDGF-BB和PDGF-AB是多种细胞类型的强效有丝分裂原,包括平滑肌细胞、结缔组织细胞、骨和软骨细胞以及一些血细胞。 PDGF储存在血小板α-颗粒中,并在血小板活化时释放。 PDGF参与许多生物学过程,包括增生、趋化性、胚胎神经元发育和呼吸小管上皮细胞发育。 本品重组人 PDGF-AA 来源于 CHO细胞, 以冻干粉形式提供,高活性、高纯度、低 …
PDGF-AA 通过 PI3K/Akt 通路促进软骨细胞间隙连接 ... - X-MOL
血小板衍生生长因子 aa (pdgf-aa) 调节软骨细胞的增殖、迁移、代谢、凋亡和细胞周期。然而,pdgf-aa 在软骨细胞间隙连接细胞间通讯中的作用尚不完全清楚。在目前的研究中,我们进行了实验以探索 pdgf-aa 对 gjic 的影响及其潜在的生物力学机制。
Platelet Derived Growth Factor AA - an overview - ScienceDirect
Platelet-Derived Growth Factor AA is a protein that is part of the PDGF family, formed by dimerization of PDGF-A and PDGF-B chains. It exhibits mitogenic and chemotactic activities and plays a role in cell proliferation and migration in various tissues, including the kidney.
New insights about the PDGF/PDGFR signaling pathway as a …
2023年5月1日 · Association of the platelet-derived growth factor and platelet-derived growth factor receptor (PDGF–PDGFR) signaling pathway with tumor progression and metastasis. In several carcinoma PDGFs stimulate tumor growth through various cellular and molecular alterations such as paracrine signaling in tumor microenvironment, promoting EMT and ...