
丙酮酸脱氢酶的结构、功能与相关疾病 - 知乎 - 知乎专栏
丙酮酸彻底氧化分解需要先转变为乙酰辅酶A,由丙酮酸脱氢酶复合体(pyruvate dehydrogenase complex,PDH或PDC)催化。 这个反应需要三种酶连续催化,依次称为E1(丙酮酸脱氢 …
Cell Metabolism | 细胞代谢的分子机制如何做?代谢顶刊CM的这篇 …
由1可知,tgf-β抑制pdk4表达,因此可能促进pdh介导的ac-coa生物合成。 敲低PDK4显著抑制PDH磷酸化并上调Ac-CoA(图2A-B)。 PDK不同剪切异构体中,PDK4显著促 …
Pyruvate dehydrogenase kinases (PDKs): an overview toward …
Pyruvate dehydrogenase kinase (PDK) can regulate the catalytic activity of pyruvate decarboxylation oxidation via the mitochondrial pyruvate dehydrogenase complex, and it …
Pyruvate dehydrogenase kinase - Wikipedia
Pyruvate dehydrogenase kinase (also pyruvate dehydrogenase complex kinase, PDC kinase, or PDK; EC 2.7.11.2) is a kinase enzyme which acts to inactivate the enzyme pyruvate …
丙酮酸脱氢酶(PDH) - Abcam中文官网
用western blot、流式细胞术或免疫细胞化学分析活细胞或细胞和组织提取物中的PDH亚基. PDH复合物缺陷是乳酸性酸中毒的重要原因,可引起儿童利氏病。大多数PDH缺乏病例是由于x -连 …
Pyruvate Dehydrogenase Kinases in the Nervous System: Their …
PDK inhibition by pyruvate facilitates PDH activation, favoring glucose oxidation and malonyl-CoA formation: the latter suppresses long-chain fatty acid (LCFA) oxidation. PDK activation by high …
Pyruvate Dehydrogenase Kinase - an overview - ScienceDirect
Pyruvate Dehydrogenase Kinase (PDK) refers to an enzyme that regulates the activity of Pyruvate Dehydrogenase (PDH) by phosphorylating it. When PDH is phosphorylated by PDK, it …
Redefining the role of hypoxia-inducible factors (HIFs) in oxygen ...
22 小时之前 · Additionally, they inhibit respiration by upregulating PDH kinase 1 (PDK1) 36,37, an enzyme that phosphorylates and inactivates PDH, reducing the conversion of pyruvate to …
Pyruvate dehydrogenase kinase 1 controls triacylglycerol …
Pyruvate dehydrogenase kinase (PDK) 1 is one of four isozymes that inhibit the oxidative decarboxylation of pyruvate to acetyl-CoA via pyruvate dehydrogenase. PDK activity is …
Targeting the PDK/PDH axis to reverse metabolic abnormalities …
2024年3月1日 · Compound g25 was discovered to target the pyruvate dehydrogenase kinase (PDK)/pyruvate dehydrogenase (PDH) axis and activate PDH. g25 improved obesity and …