丙酮酸彻底氧化分解需要先转变为乙酰辅酶A，由丙酮酸脱氢酶复合体（pyruvate dehydrogenase complex，PDH或PDC）催化。 这个反应需要三种酶连续催化，依次称为E1（丙酮酸脱氢 …

由1可知，tgf-β抑制pdk4表达，因此可能促进pdh介导的ac-coa生物合成。 敲低PDK4显著抑制PDH磷酸化并上调Ac-CoA（图2A-B）。 PDK不同剪切异构体中，PDK4显著促 …

Pyruvate dehydrogenase kinase (PDK) can regulate the catalytic activity of pyruvate decarboxylation oxidation via the mitochondrial pyruvate dehydrogenase complex, and it …

Pyruvate dehydrogenase kinase (also pyruvate dehydrogenase complex kinase, PDC kinase, or PDK; EC 2.7.11.2) is a kinase enzyme which acts to inactivate the enzyme pyruvate …

用western blot、流式细胞术或免疫细胞化学分析活细胞或细胞和组织提取物中的PDH亚基. PDH复合物缺陷是乳酸性酸中毒的重要原因，可引起儿童利氏病。大多数PDH缺乏病例是由于x -连 …

PDK inhibition by pyruvate facilitates PDH activation, favoring glucose oxidation and malonyl-CoA formation: the latter suppresses long-chain fatty acid (LCFA) oxidation. PDK activation by high …

Pyruvate Dehydrogenase Kinase (PDK) refers to an enzyme that regulates the activity of Pyruvate Dehydrogenase (PDH) by phosphorylating it. When PDH is phosphorylated by PDK, it …

22 小时之前 · Additionally, they inhibit respiration by upregulating PDH kinase 1 (PDK1) 36,37, an enzyme that phosphorylates and inactivates PDH, reducing the conversion of pyruvate to …

Pyruvate dehydrogenase kinase (PDK) 1 is one of four isozymes that inhibit the oxidative decarboxylation of pyruvate to acetyl-CoA via pyruvate dehydrogenase. PDK activity is …

2024年3月1日 · Compound g25 was discovered to target the pyruvate dehydrogenase kinase (PDK)/pyruvate dehydrogenase (PDH) axis and activate PDH. g25 improved obesity and …