Periodontal ligament stem cells (PDLSCs), which reside in the perivascular space of the periodontium, possess characteristics of mesenchymal stem cells and are a promising tool for periodontal regeneration. Recently, great progress has been made in PDLSC transplantation.

The prerequisites for healing include the presence and migration of specific cell populations with regenerative potential (eg, pulp or PDL progenitor cells) and the absence of contamination, foreign bodies, and/or bacteria.

Recent observations show that vitamin D and the antimicrobial peptide LL‐37 antagonize lipopolysaccharide‐stimulated PDL cell production of pro‐inflammatory cytokines. Secretory leukocyte protease inhibitor is endogenously expressed by PDL cells, and this protein negatively regulates PDL cell‐evoked cytokine production.

Periodontal ligament stem cells are stem cells found near the periodontal ligament of the teeth. These cells have shown potential in the regeneration of not only the periodontal complex but also other dental and non-dental tissues.

2022年12月25日 · Periodontal ligament progenitor cells (PDL cells) are a heterogenous group of cells of fibroblastic and osteoblastic mesenchymal lineages that may be at different stages of differentiation and lineage commitment. 5 Numerous studies have demonstrated that PDL cells or PDL stem cells (PDLSCs) can differentiate into a variety of cell types ...

2021年5月7日 · Periodontal ligament (PDL) is a uniquely differentiated tissue that anchors the tooth to the alveolar bone socket and plays key roles in oral function. PDL cells can respond...

2019年8月1日 · Several types of mesenchymal stem cells (MSCs) have been characterized in the oral cavity, and those derived from the periodontal ligament (PDL) first isolated by our group in 2005, can be expanded in a xeno-free medium preserving morphological features and markers associated with pluripotency.

The PDL is a fibrous connective tissue derived from the dental follicle and originates from neural crest cells. PDL connects the cementum to alveolar bone and maintains the root of the tooth in the alveolar socket by acting as a ‘shock absorber’ during mastication.

2023年8月8日 · In this study, Leptin receptor+ (Lepr+) cells are identified as a distinct periodontal ligament stem cell (PDLSC) population by single-cell RNA sequencing and lineage tracing. These Lepr+ PDLSCs are located in the peri-vascular niche, possessing multilineage potential and contributing to tissue repair in response to injury.

2022年6月21日 · Periodontal ligament stem cells (PDLSCs) are the promising source for neuroregenerative applications that can improve the injured microenvironment of the damaged neural system. They provide neuronal progenitors and neurotrophic, anti-apoptotic and anti-inflammatory factors.