Lineal (poloxamers or Pluronic ®) or X-shaped (poloxamines or Tetronic ®) amphiphilic tri-block copolymers of poly (ethylene oxide) and poly (propylene oxide) (PEO-PPO-PEO) have been broadly explored for controlled drug delivery in different regenerative medicine approaches.

2022年4月1日 · The poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) triblock copolymers, known as poloxamer (Pluronic®), are amphiphilic polymers that possess unique thermo-responsive properties.

Poloxamer 188, a triblock copolymer of poly (ethylene oxide) (PEO) and poly (propylene oxide) (PPO), protects cellular membranes from various stresses. Though numerous block copolymer variants exist, evaluation of alternative architecture, composition, and size has been minimal.

1997年10月1日 · Applications of amphiphilic block copolymers, and in particular PEO/PPO copolymers, are reviewed in [15-,29,30-,31,32,33-]. We start this review with the topic of PEO-PPO-PEO block copolymers in dilute aqueous solutions (micelles), where new information on micelle formation and structure in water and in the presence of cosolutes is examined.

2018年3月8日 · Lineal (poloxamers or Pluronic ®) or X-shaped (poloxamines or Tetronic ®) amphiphilic tri-block copolymers of poly (ethylene oxide) and poly (propylene oxide) (PEO-PPO-PEO) have been broadly explored for controlled drug delivery in …

聚氧丙烯聚氧乙烯共聚物溶液 (PEO-PPO-PEO)是用共价键将亲水的PEO链段和疏水的PPO链段链结在一起的高分子化合物，是一类非离子型的高分子表面活性剂，商品名Pluronic (BASF公司)或Poloxamer (ICI公司)，然而聚氧丙烯聚氧乙烯共聚物溶液本身结构所具有的的端羟基活性很小，限制了其在很多领域的进一步拓展应用，因此对聚氧丙烯聚氧乙烯共聚物溶液共聚物端羟基修饰 …

2020年4月4日 · Here, we report the distribution of P188 in a model lipid bilayer comprising 1-palmitoyl-2-oleoyl-glycero-3-phosphocholine (POPC) using neutron reflectivity (NR) and atomic force microscopy (AFM). We also investigated the association of a PEO homopolymer (PEO8.4K; Mn = 8400 g/mol) that does not protect living cell membranes.

2015年11月5日 · Poly(ethylene oxide)–poly(propylene oxide)–poly(ethylene oxide) triblock copolymers, Pluronic (PEO–PPO–PEO), are water-soluble nonionic polymer surfactants and can self-assemble into micelles above the critical micelle temperature (CMT) or the critical micelle concentration (CMC) in aqueous solutions [1], [2], [3], [4].

2019年11月25日 · We therefore studied the effects of injecting a thermosensitive hydrogel based on PEO–PPO–PEO poloxamers for the in situ release of an rAAV encoding for the chondrogenic sox9 transcription factor on the repair of full-thickness chondral defects in a clinically relevant large animal model in vivo.

聚氧丙烯聚氧乙烯共聚物溶液 (PEO-PPO-PEO)是用共价键将亲水的PEO链段和疏水的PPO链段链结在一起的高分子化合物，是一类非离子型的高分子表面活性剂，商品名Pluronic (BASF公司)或Poloxamer (ICI公司)，然而聚氧丙烯聚氧乙烯共聚物溶液本身结构所具有的的端羟基活性很小，限制了其在很多领域的进一步拓展应用，因此对聚氧丙烯聚氧乙烯共聚物溶液共聚物端羟基修饰 …