2025年1月31日 · Purpose: Taxane-induced peripheral neuropathy (TIPN) is a dose-limiting toxicity of paclitaxel in patients with cancer. TIPN prediction is challenging although patients with higher systemic paclitaxel exposure have higher TIPN risk. This study aimed to identify protein predictors of TIPN and paclitaxel pharmacokinetics (PK).

2022年8月9日 · We explored the impact of persistent sensory and motor taxane-induced peripheral neuropathy (TIPN) symptoms on health-related quality of life (HRQL) among early-stage breast cancer survivors (ESBCS).

TiPN的发生可能与沙利度胺抗血管新生作用相关，致使神经纤维缺血、TNFα表达下调、NF–κB通路阻断，进而诱发神经纤维的损伤、促发神经细胞死亡等 [16]。 其他药物，包括长春新碱相关PN的发生可能与药物阻滞微管蛋白的聚合有关 [10]；而顺铂引起PN可能是其直接损伤背根神经节的结果，也可能涉及周围和中枢感觉神经元的退化 [17]。 除详细询问病史、进行症状与体征评估外，应按条件开展神经功能评分及神经电生理检测。 对骨髓瘤的发病情况、病程，是否存在MM …

2024年3月1日 · Recent findings: Studies show varying rates of TIPN persistence, with an estimated 30-40% and 40-60% resolving by 1- and 3-year post-treatment. TIPN in the feet and motor symptoms show less resolution post-treatment.

Taxane-induced peripheral neuropathy (TIPN) occurs in up to 70% of patients, impacting quality of life both during and after treatment. TIPN typically manifests as tingling and numbness in the hands and feet and can cause irreversible loss of function of peripheral nerves. TIPN can be dose-limiting, potentially impacting clinical outcomes.

2019年8月29日 · 紫杉类药物引起的周围神经毒性（tipn） 然而，紫杉类药物引起的周围神经毒性（Taxane-induced peripheral neuropathy，TIPN）是剂量限制性毒性，主要表现为肢端麻木、疼痛等感觉异常，甚至运动受限。

2024年5月29日 · The primary endpoint was the occurrence of TIPN, defined as an increase of >8 points over baseline in the EORTC QLQ-CIPN20 sensory subscale score at any follow-up assessment through week 24. A 2-step training/test approach was used to develop a TIPN risk prediction model.

2025年1月31日 · Taxane-induced peripheral neuropathy (TIPN) is a dose-limiting toxicity of paclitaxel in patients with cancer. TIPN prediction is challenging although patients with higher systemic paclitaxel exposure have higher TIPN risk. This study aimed to identify protein predictors of TIPN and paclitaxel pharmacokinetics (PK).

Taxane-induced peripheral neuropathy (TIPN) is a common toxicity and confers significant morbidity with no validated therapies. Literature detailing TIPN is inconsistent in reporting its frequency, severity, risk factors, impact upon treatment course, and management practices.

多发性骨髓瘤周围神经病变（MMPN）是指在多发性骨髓瘤疾病过程中出现任何形式的周围神经 病变（如损伤、炎症或变性），临床出现感觉神经、运动神经及自主神经受损的症状或体征 1。 1.Delforge M, et al. Lancet Oncol. 2010 ;11 (11):1086-95. 2.Vangsted A, et al. Eur J Haematol. 2012 ;88 (2):93-117. 3.Corthals SL, et al. Haematologica. 2011 Nov;96 (11):1728-32. 4.Facon T, et al. Lancet. 2007 ;370 (9594):1209-18.