2023年10月16日 · To decode the cellular and circuit organization of such diverse functions, we employed spatially resolved single-cell transcriptome profiling of the adult mouse PFC. Results revealed that PFC...

2022年3月31日 · Prefrontal cortex (PFC) is the cognitive center that integrates and regulates global brain activity. However, the whole-brain organization of PFC axon projections...

2021年6月16日 · The principal rhythms encountered in the mouse PFC are the delta (1–4 Hz), theta (8–12 Hz), and gamma (30–80 Hz) oscillations. An increasing amount of data highlight the mouse PFC as a rich oscillatory hub, with specific prefrontal oscillations being tightly coupled to distinct behavioral and cognitive states (Sohal, 2016).

2021年6月16日 · The recent surge of studies of the PFC in mice holds promise for evolvement of present theories and development of novel concepts, particularly regarding principles shared across mammals. Here we review recent empirical work on the mouse PFC capitalizing on the experimental toolbox currently privileged to studies in this species.

2024年10月1日 · Here we record single-units in three neighboring mouse medial PFC (mPFC) subregions—supplementary motor area (MOs), dorsomedial PFC (dmPFC), and ventromedial (vmPFC)—during a freely-behaving...

2022年4月4日 · Research synthesis of the functions of the mouse PFC. PFC的功能主要是：信息表征和产生有目的的动作。 对PFC功能的研究一般是通过把神经元活动与行为变量关联起来的实验建立起来的，通常辅以干扰实验。 整合了2011-2020年100篇有关PFC功能的文献，存放在 https://carlenlab.org ...

In this review, we describe the cellular diversity of the rodent mPFC, the impact of long-range afferents, and the specificity of local microcircuits. We highlight similarities and differences with other cortical areas, illustrating how the circuit organization of the mPFC may give rise to its unique functional roles.

2019年11月28日 · To generate a comprehensive cell map of mouse PFC, we dissect this brain region from acute coronal sections of young (3 weeks) and adult mouse brains (8-10 weeks). After cell dissociation, single cells are captured with the 10X Chromium platform (10X Genomics), followed by cDNA synthesis, library preparation and high-throughput sequencing.

2021年1月1日 · The mouse prefrontal cortex (PFC) encompasses a collection of agranual brain regions in the rostral neocortex and is considered to be critically involved in the neuronal computations underlying intentional behaviors.

2021年4月21日 · We show that mice readily learn rule-based categorization and generalize to novel stimuli. Over the course of learning, neurons in the prefrontal cortex display distinct dynamics in acquiring...