Primordial germ cells (PGCs) are the embryonic precursors of sperm and oocytes, which transmit genetic/epigenetic information across generations. Mouse PGC and subsequent gamete development can be fully reconstituted in vitro, opening up new avenues for germ cell studies in biomedical research.

Primordial germ cells (PGCs) are the embryonic precursors of sperm and oocytes, which transmit genetic/epigenetic informa-tion across generations. Mouse PGC and subsequent gamete development can be fully reconstituted in vitro, opening up new avenues for germ cell studies in biomedical research.

2022年5月24日 · 借助pgc报告细胞系（bv+sc+，分别指示prdm1与dppa3）、细胞分选等活细胞分析技术，研究人员将primed态细胞诱导产生的bv+sc+细胞移植到雄性生殖缺陷小鼠睾丸中，发现这些移植的细胞可以发育为精子。

Primordial germ cells (PGCs) are the embryonic progenitors of sperm and egg cells. Mammalian PGCs are thought to actively migrate from the yolk sac endoderm over long distances across the embryo to reach the somatic genital ridges. The general principles of mammalian PGC development were discovered …

2021年9月2日 · 二氰基吡嗪 (DPZ) 是一种研究相对较少的有机光氧化还原催化剂，通过其在有机合成中的催化活性显示出巨大的潜力，需要合成界的关注。 可见光有机光氧化还原催化已成为有机合成转化的宝贵工具，因为它与有机底物协同工作，并且已知为有机转化创造独特的化学环境。 二氰基吡嗪 (DPZ) 是一种研究相对较少的有机光氧化还原催化剂，通过其在有机合成中的催化活性显示出巨大的潜力，需要合成界的关注。

2017年10月17日 · 他们使用自主发展的双氰基吡嗪衍生的发色团（ dicyanopyrazine-derived chromophore 即 DPZ ）作为可见光催化剂，并使用手性胍的四氟硼酸盐作为添加剂，成功发展了可见光诱导的高立体选择性的 1,2-二酮不对称还原反应。

2019年4月26日 · 为了突破不对称氢键催化因氢键作用能量较低所面临的反应类型的局限性，通过独立发展一种高效、易于制备的二腈基吡嗪衍生物，即DPZ有机可见光催化剂（ RSC Adv., 2014, 16, 672; Angew. Chem.

As an extension of the successful dicyanopyrazine photoredox catalysts, a series of X-shaped push-pull molecules with a systematically altered structure were designed and facilely synthesized;...

2021年9月2日 · Dicyanopyrazine (DPZ), a relatively lesser researched organophotoredox catalyst, has shown great potential through its catalytic activity in organic synthesis and necessitates...

2024年3月18日 · We established transgene-free induced pluripotent stem cell (cjiPSC) lines from foetal and postnatal fibroblasts. These cjiPSCs, cultured in defined and feeder-free conditions, can be differentiated into precursors of mesendoderm and subsequently into cjPGC-like cells (cjPGCLCs) with a transcriptome similar to human PGCs/PGCLCs.