Prostaglandin (PG) D 2 and PGE 2 are positional isomers; however, they sometimes exhibit opposite physiological functions, such as in cancer development. Because DP receptors are considered to be a duplicated copy of EP2 receptors, PGD 2 and PGE 2 cross-react with both receptors. These prostanoids may act as biased agonists for each receptor.

pgh2是多种类花生酸的前体，在不同细胞中可由特异性的前列腺素合成酶催化，形成pgi2、pgd2、pge2和txa2等。 凝血恶烷酸（TX）由血小板合成，有一个含氧的六元杂环，环中还有一个氧。

Prostaglandin (PG) E2 and PGD2, which are biosynthesized from arachidonic acid generated by enzymatic cleavage of membrane phospholipid in response to various stimuli, play key roles in multiple brain pathophysiological processes, including modulation of synaptic plasticity, neuroinflammation, and s …

前列腺素D2（Prostaglandin D2，PGD2）是哺乳动物脑内含量最丰富的一种前列腺素。 研究表明PGD2是最强效的内源性睡眠促进物质，诱导生理性睡眠；哮喘的慢性炎症反应过程中有PGD2参与；并且发现前列腺素D2及其受体与哺乳动物的生殖密切相关。

2021年1月25日 · Eicosanoids profiling in triple negative breast cancer (TNBC) reveals miR-155 positively correlates with PGE2/PGD2 ratio and related metabolic enzyme expression. a Expression-correlation analysis of miR-155 (in blue) and PGE2/PGD2 ratio (in red) measured in human TNBC specimens (n = 20).

There are five subtypes of PGs, namely PGE2, PGI2, PGD2, PGF2α, and thromboxane A2 (TXA2). PGs exert distinct roles by combining to a diverse family of membrane-spanning G protein-coupled prostanoid receptors. The distribution of these PGs, their specific synthases and receptors vary a lot in the kidney.

前列腺素 (PG) D 2和 PGE 2是位置异构体；然而，它们有时表现出相反的生理功能，例如在癌症发展中。 因为 DP 受体被认为是 EP2 受体的复制副本，所以 PGD 2和 PGE 2与两种受体发生交叉反应。 这些前列腺素可以作为每个受体的偏向激动剂。 在回顾这一领域时，提出了一个假设，从受体的进化、突变和偏向活动的角度解释这些前列腺素的相反作用。 先前的研究结果表明，DP 受体的突变/变异比全球个体中的 EP2 受体更多，这表明 DP 受体仍处于快速进化阶段。 这些前列 …

PGE2 is the principal mediator of fever, and both PGE2 and PGD2 regulate sleep-wake behavior. The extent to which PGE2 and PGD2 are involved in the effect of LPS on NREM sleep remains to be clarified.

2020年11月9日 · Prostaglandin (PG) D 2 and PGE 2 are positional isomers; however, they sometimes exhibit opposite physiological functions, such as in cancer development. Because DP receptors are considered to be a duplicated copy of EP2 receptors, PGD 2 and PGE 2 cross-react with both receptors. These prostanoids may act as biased agonists for each receptor.

2020年11月9日 · Here, we describe a method exploiting the cationization of PGs with silver ions for enhanced sensitivity and tandem MS to distinguish the biologically relevant PG isomers PGE2, PGD2, and...