Prostacyclin (also called prostaglandin I2 or PGI2) is a prostaglandin member of the eicosanoid family of lipid molecules. It inhibits platelet activation and is also an effective vasodilator. When used as a drug, it is also known as epoprostenol. [1] . The terms are sometimes used interchangeably. [2]

IP binds to and mediates the biological actions of prostacyclin (also termed prostaglandin I 2, PGI 2, or when used as a drug, epoprostenol). IP is encoded in humans by the PTGIR gene.

Unlike most P450 enzymes, PGIS does not require molecular oxygen (O 2). Instead it uses its heme cofactor to catalyze the isomerization of prostaglandin H 2 to prostacyclin. Prostaglandin H 2 is produced by cyclooxygenase in the first committed step of prostaglandin biosynthesis.

Aug 14, 2024 · Prostaglandin I2 (PGI2), also known as prostacyclin, is another important prostaglandin synthesized from arachidonic acid. It is primarily produced by endothelial cells and plays a crucial role in vascular homeostasis.

Nov 12, 2024 · Prostacyclin replacement therapies have been shown to improve hemodynamic parameters and right heart function, including cardiac output and pulmonary vascular resistance (PVR), improve functional...

May 30, 2022 · Prostacyclin (PGI 2) is a natural hormone that has primarily been explored for its potent vasodilation activity and inhibition of platelet aggregation. The chemical structure of prostacyclin has intrinsic instability in aqueous solutions that limited its analysis and clinical use.

Jun 21, 2024 · PGI2 receptor agonists work by targeting and activating the prostacyclin receptor (IP receptor) on the surface of certain cells. When prostacyclin binds to its receptor, it triggers a cascade of intracellular events leading to various biological effects.

Thrombozytenaggregationshemmung: PGI 2 ist ein funktioneller Antagonist des Thromboxans. Weitere Wirkungen sind Temperaturanstieg (Fieber), Steigerung der Gefäßpermeabilität, Erhöhung der Schmerzempfindlichkeit und Stimulierung der Bikarbonatsekretion.

前列环素[1] （英語： Prostacyclin，简称为 PGI2）是 脂类 中 类花生酸 家族中的一个成员，分子中有一个次级五元环，其前体是 花生四烯酸 或其他二十碳不饱和脂肪酸。 前列环素会抑制 血小板 介导的凝集过程并有强烈的血管舒张作用，因此在 凝血作用 中，受损血管内皮的前列环素生成量会减少，这有利于血小板的聚集。

PGI2, also known as prostacyclin, is a hormone-like substance produced by endothelial cells, which are cells lining the blood vessels. It is a type of