AR and PI3K/AKT in Prostate Cancer: A Tale of Two ... - PubMed
2023年1月20日 · A significant interaction between AR and the PI3K/AKT/mTOR signaling pathway has been shown in PCa. This review centers on the current scene of different AR and …
AR Signaling and the PI3K Pathway in Prostate Cancer
2017年4月15日 · Herein we outline the role of the PI3K pathway in prostate cancer and, in particular, its association with androgen receptor signaling in the pathogenesis and evolution …
AR Signaling and the PI3K Pathway in Prostate Cancer - MDPI
2017年4月15日 · Interactions between the AR and PI3K pathways may be a mechanism of treatment resistance and inhibitors of this pathway have been developed with variable …
PI3K/Akt inhibition promotes AR activity and prostate cancer cell ...
2025年2月1日 · PI3K/Akt blockade activates AR via p35-CDK5 in PCa, causing resistance. p35-CDK5 knockdown improves PI3K/Akt therapy, suggesting a therapeutic target. Aberrant …
AR and PI3K/AKT in Prostate Cancer: A Tale of Two …
2023年1月20日 · A significant interaction between AR and the PI3K/AKT/mTOR signaling pathway has been shown in PCa. This review centers on the current scene of different AR and …
PI3K/Akt inhibition promotes AR activity and prostate cancer cell ...
Aberrant PI3K/Akt activation is linked to prostate cancer (PCa) malignancy, while androgen receptor (AR) is critical in early-stage PCa development. Investigating the interaction between …
Reciprocal Feedback Regulation of PI3K and Androgen ... - Cell …
2011年5月17日 · Prostate cancer is characterized by its dependence on androgen receptor (AR) and frequent activation of PI3K signaling. We find that AR transcriptional output is decreased …
The PI3K-AKT-mTOR Pathway and Prostate Cancer: At the Crossroads of AR ...
2020年6月25日 · Oncogenic activation of the phosphatidylinositol-3-kinase (PI3K), protein kinase B (PKB/AKT), and mammalian target of rapamycin (mTOR) pathway is a frequent event in …
Important Roles of PI3K/AKT Signaling Pathway and Relevant …
2024年11月1日 · We primarily investigated non-AR pathways as potential targets, focusing on the PI3K/AKT signaling pathway, which is particularly important and meaningful. Six primary …
Reciprocal feedback regulation of PI3K and androgen receptor …
Prostate cancer is characterized by its dependence on androgen receptor and frequent activation of PI3K signaling. We find that AR transcriptional output is decreased in human and murine …