It inhibits STAT1-mediated gene activation and the DNA binding activity, binds to Gu protein/RNA helicase II/DEAD box polypeptide 21, and interacts with androgen receptor (AR). It functions in testis as a nuclear receptor transcriptional coregulator and may have a role in AR initiation and maintenance of spermatogenesis. [7]

2024年12月25日 · PIAS1 (Protein Inhibitor Of Activated STAT 1) is a Protein Coding gene. Diseases associated with PIAS1 include Nephronophthisis and Germ Cell Cancer. Among its related pathways are Transport of the SLBP independent Mature mRNA and Transcription-Coupled Nucleotide Excision Repair (TC-NER).

PIAS1包含了一个内在的激活结构域,对雄激素受体的转录有双向的功能,使得低水平表达能抑制转录,高水平的表达能诱导转录。 由于PIAS1中该结构域的存在,PIAS1与其他成员相比在调节雄激素受体转录时的作用方向相反。 PIASx分为PIASx α和PIASxβ,两者为同一个基因编码的不同剪接体所对应的蛋白质,除C端区域外,其余序列均一致;在C端PIASx α 只能利用单一的外显子,而PIASx β有两个外显子可供选择。 PIASx的这两种亚型均以独立的核小体形式定位于细胞核,但两种亚型核小 …

2020年2月28日 · PIAS1 (protein inhibitor of activated STAT1)蛋白是一种可以抑制信号转导与转录激活子1 (STAT1)的特异性抑制蛋白，同时具有SUMO连接酶E3的活性，参与多种转录因子的活性调控和多种蛋白质的SUMO化修饰。 PIAS1在肿瘤细胞的生长进程中具有关键作用，并可因不同类型的肿瘤而发挥促进或抑制肿瘤进展的作用，是癌症治疗的一个重要潜在靶点，并可作为抗炎因子调节炎症细胞粘附和抑制炎症损伤。 在肺癌、前列腺癌、乳腺癌、淋巴瘤等肿瘤中，PIAS1可 …

该基因编码激活 STAT (PIAS) 蛋白抑制剂家族的成员。 PIAS 蛋白作为 SUMO E3 连接酶发挥作用，并通过介导靶蛋白的 SUMO 化在许多细胞过程中发挥重要作用。 这种蛋白质作为众多细胞通路的转录辅助调节因子发挥着核心作用，包括 STAT1 和核因子 kappaB 通路。 交替剪接导致多个转录本变体。 [RefSeq 提供，2016 年 3 月] This gene encodes a member of the protein inhibitor of activated STAT (PIAS) family.

2025年3月8日 · Title: SUMOylation of SMAD4 by PIAS1 in Conjunction with Vimentin Upregulation Promotes Migration Potential in Non-Small Cell Lung Cancer. Crosstalk between SUMOylation and ubiquitylation controls DNA end resection …

2020年2月11日 · Increasing evidence shows that PIAS1 is overexpressed in various human malignancies, including prostate and lung cancers. Here we used quantitative SUMO proteomics to identify potential...

2017年5月1日 · PIAS1（protein inhibitor of activated signal transducer and activators of transcription 1）蛋白是一种可以抑制信号转导与转录激活子1（signal transducer and activators of transcription 1,...

2024年4月15日 · Protein inhibitor of activated signal transducer and activators of transcription 1 (PIAS1) is a small ubiquitin-like modifier (SUMO) E3 ligase, which plays a crucial role in variety of biological processes both in vitro and in vivo, such as inflammation [9].

2005年8月1日 · PIAS1 has specific effects on cytokine-mediated signalling by selectively regulating a subset of interferon- or tumour-necrosis-factor-responsive genes. PIAS1 is important in innate immunity. A...

PIAS1 (protein inhibitor of activated signal transducer and activators of transcription 1)蛋白是一种可以抑制信号转导与转录激活子1 (signal transducer and activators of transcription...

2012年11月29日 · Protein inhibitor of activated signal transducer and activator of transcription-1 (PIAS1) is known to function as small ubiquitin-like modifier (SUMO) E3 ligase as well as transrepressor. The aim of the study is to elucidate the regulatory mechanisms for these 2 different functions, especially with respect to endothelial inflammation.

2004年8月15日 · Using PIAS1-deficient cells, we show that PIAS1 selectively regulates a subset of IFN-γ- or IFN-β-inducible genes by interfering with the recruitment of STAT1 to the gene promoter. The...

2024年3月24日 · Most frequently reported PIAS family members in cancer development are PIAS1 and PIAS3. SUMOylation as post-translational modifier regulates several cellular machineries. PIAS proteins as SUMO E3 ligase factor promotes SUMOylation of transcription factors tangled cancer cells for survival, proliferation, and differentiation.

2014年2月24日 · We report here that the PIAS1 SUMO ligase is involved in the progression of breast tumorigenesis. Elevated PIAS1 expression was observed in breast tumor samples. PIAS1 knockdown in breast cancer cells reduced the subpopulation of tumor-initiating cells, and inhibited breast tumor growth in vivo.

2007年6月1日 · Protein inhibitor of activated STAT1 (PIAS1), a transcriptional regulator that possesses small ubiquitin-related modifier (SUMO) E3 ligase activity, inhibits immune responses by selectively blocking the binding of NF-κB and STAT1 to gene promoters.

2023年8月16日 · Our study proved that PIAS1 suppressed vascular endothelial injury and atherosclerotic plaque formation in mouse models of diabetes via the RUNX3/TSP-1 axis. Diabetes is a metabolic disease characterized by hyperglycemia accompanied by carbohydrate, fat, and protein metabolism disturbance, with increasing incidence worldwide [1].

The discovery of PIAS3 was first published in 1997. The discovery was made while the JAK-STAT pathway was being studied. [1] The discovery of other PIAS proteins, including PIAS1, PIASxα, PIASxβ, and PIASy, was published the following year. [2] The interaction between STATs and PIASs was characterized by the yeast two-hybrid assay. [1] [2] PIAS proteins were named based on their ability to ...

2020年2月11日 · The protein inhibitor of activated STAT1 (PIAS1) is an E3 SUMO ligase that plays important roles in various cellular pathways. Increasing evidence shows that PIAS1 is overexpressed in various human malignancies, including prostate and lung cancers. Here we used quantitative SUMO proteomics to identi …

2010年10月22日 · We report here that the SUMO E3 ligase PIAS1 restricts the differentiation of natural T reg cells by maintaining a repressive chromatin state of the Foxp3 promoter. PIAS1 acts by binding to the Foxp3 promoter to recruit DNA methyltransferases and heterochromatin protein 1 for epigenetic modifications.