PI3K-Akt信号通路详解：通路激活+通路组成+通路串联+通路检 …
PI3K-Akt信号通路是细胞中一个关键的信号传导网络，它可被多种细胞刺激或毒性损伤所激活，并在调控转录、翻译、增殖、生长和存活等基本细胞功能中扮演重要角色。 当生长因子与细胞 …
磷脂酰肌醇3-激酶(PI3K)信号通路 - 知乎 - 知乎专栏
磷脂酰肌醇3-激酶 (PI3Ks)蛋白家族参与细胞存活、生长、代谢和血糖稳态等多种细胞功能的调控。 PI3K激酶活性升高通常与多种癌症相关。顾名思义，PI3Ks磷酸化磷脂酰肌醇PI（一种膜磷 …
Oncogenic Mutations of PIK3CA in Human Cancers - PMC
This concept has been demonstrated by the mutual exclusivity found between APC and beta-catenin mutations (Morin et al. 1997; Sparks et al. 1998) or KRAS and BRAF mutations …
APC/PIK3CA mutations and β-catenin status predict tankyrase
2023年11月15日 · Short APC mutant CRC cells exhibited high/intermediate sensitivities to tankyrase inhibitors in vitro and in vivo. Active β-catenin levels correlated with inhibitor …
Dual PI3K/mTOR Inhibition in Colorectal Cancers with APC and …
In human CRCs, PIK3CA mutations most commonly occur concomitantly with loss of Adenomatous Polyposis Coli (APC). Here treatment strategies are investigated that target the …
PIK3CA hotspot mutation generates a shared neoantigen ... - Nature
2022年4月28日 · Activating mutations in PIK3CA, a driver oncogene that encodes phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit α-isoform (PI3Kα), are among …
Dual PI3K/mTOR Inhibition in Colorectal Cancers with APC and …
In human colorectal cancers, PIK3CA mutations most commonly occur concomitantly with loss of adenomatous polyposis coli (APC). Here, treatment strategies are investigated that target the …
磷脂酰肌醇 3 激酶 | Phosphatidylinositol 3-kinase (PI3K) | MCE
Phosphatidylinositol 3-kinase (PI3K) is lipid kinases that regulate diverse cellular processes including proliferation, adhesion, survival, and motility. Dysregulated PI3K pathway signaling …
PI3K Akt 通路 | Cell Signaling Technology
PI3K 相关激酶 (PIKK) 家族成员，包括 DNA-PK，也同样能在 Akt 丝氨酸 473 位点将其磷酸化。 Akt 可被蛋白磷酸酶 2A (PP2A) 以及 PH-结构域富含亮氨酸-重复-包含蛋白磷酸酶 (PHLPP1/2) …
肠癌PIK3K/AKT/mTOR信号通路与靶向治疗 - 知乎 - 知乎专栏
当细胞外生长因子与其受体结合后，可以促进pi3k激活，使PIP2转变为PIP3，该转变过程，可以被肿瘤抑制因子 PTEN 负调控。 PIP3可以将激酶 PDK1 和AKT招募至细胞膜，使AKT发 …