SIRT6 deacetylates PKM2 to suppress its nuclear localization and ...
2016年2月2日 · As a result of SIRT6-mediated deacetylation, PKM2 nuclear protein kinase and transcriptional coactivator functions are abolished. Thus, SIRT6 suppresses PKM2 oncogenic …
SIRT6 deacetylates PKM2 to suppress its nuclear localization and ... - PNAS
2016年1月19日 · Several previous studies indicate that SIRT6 has tumor-suppressor functions, whereas PKM2 has been reported to promote cell proliferation and tumorigenesis. Based on …
As a result of SIRT6-mediated deacetylation, PKM2 nuclear protein kinase and transcriptional coactivator functions are abolished. Thus, SIRT6 suppresses PKM2 oncogenic functions, …
SIRT6, a Mammalian Deacylase with Multitasking Abilities
SIRT6-dependent deacetylation results in the nuclear export of PKM2 and the suppression of the oncogenic functions of PKM2. In different studies, SIRT6 has been shown to work as a potent …
SIRT6 serves as a polyhedron in glycolytic metabolism and ageing ...
2022年6月1日 · These results suggest that SIRT6 deacetylates PKM2 at K433, thereby preventing cancer. The SIRT6-mediated reduction in non-small-cell lung cancer (NSCLC) …
SIRT6 deacetylates PKM2 to suppress its nuclear ... - ResearchGate
2016年1月20日 · SIRT6 has been shown to deacetylate nuclear PKM2, leading to inhibited STAT3 phosphorylation, which disrupted NF-κB-IL-6-STAT3 axis activation, inhibiting the …
SIRT6通过PKM2抑制癌症发生和进展的分子机制的研究_百度百科
本研究将为明确SIRT6抑制癌症发生和进展提供分子水平的证据，为治疗PKM2介导的肿瘤性疾病提供药物新靶标和分子靶点。 PKM2是糖代谢途径的一个成员，它将PEP和ADP催化形 …
Inhibiting Protein Kinase Activity of Pyruvate Kinase M2 by …
2021年2月1日 · In this study, we investigated whether and how SIRT2 deacetylase regulated the protein kinase function of PKM2 in T helper type 17 cell‒mediated inflammatory responses in …
SIRT6 deacetylates PKM2 to suppress its nuclear localization and ... - PNAS
2016年1月19日 · Here we report that SIRT6 binds to and deacetylates nuclear PKM2 (pyruvate kinase M2) at the lysine 433 residue. PKM2 is a glycolytic enzyme with nonmetabolic nuclear …
SUMOylation disassembles the tetrameric pyruvate kinase M2 …
2021年1月20日 · SUMOylation of PKM2 lysine 270 (K270) triggered conformation change from tetrameric to dimeric of PKM2, reduced PK activity, and led to nuclear translocation of PKM2. …