Blocking Double-Stranded RNA-Activated Protein Kinase PKR by …
2012年2月29日 · In this study, we found that JEV NS2A could antagonize PKR-mediated growth inhibition in a galactose-inducible PKR-expressing yeast system. In human cells, PKR …
Molecular pathogenesis of Japanese encephalitis and possible ...
It has also been reported that NS2A plays a vital role in JEV infection by suppressing the antiviral response generated by host cells, where NS2A suppresses protein kinase (PKR)-induced cell …
Blocking Double-Stranded RNA-Activated Protein Kinase PKR by …
2012年10月1日 · ABSTRACTJapanese encephalitis virus (JEV) is an enveloped flavivirus with a single-stranded, positive-sense RNA genome encoding three structural and seven …
Blocking double-stranded RNA-activated protein kinase PKR by ... - PubMed
The interferon (IFN)-induced double-stranded RNA (dsRNA)-activated protein kinase (PKR) phosphorylates the eukaryotic translation initiation factor 2α subunit (eIF2α) after sensing viral …
Japanese encephalitis virus infection modulates the expression of ...
2013年9月1日 · The levels of protein kinase R (PKR) was consistently increased in JEV-infected cells than mock-infected cells at all time points. However, it is to be noted that at 24 h post …
[PDF] Blocking Double-Stranded RNA-Activated Protein Kinase PKR …
In this study, we found that JEV NS2A could antagonize PKR-mediated growth inhibition in a galactose-inducible PKR-expressing yeast system. In human cells, PKR activation, eIF2α …
日本脑炎病毒sfRNA靶向PKR和IFITM2的翻译抑制细胞干扰素应答
本研究旨在探究日本脑炎病毒 (JEV)感染细胞后产生非编码亚基因组RNA (sfRNA)的生物学功能.应用Northern blot检测JEV感染细胞产生sfRNA的动态特征;通过Western blot和qPCR检测JEV感 …
Japanese Encephalitis Virus Core Protein Inhibits Stress Granule ...
2013年1月1日 · In this study, we found that expression of Japanese encephalitis virus (JEV) core protein inhibits SG formation. Caprin-1 was identified as a binding partner of the core protein …
PKR-mediated stress response enhances dengue and Zika virus …
2023年9月21日 · In the present work, we show that PKR is the main kinase leading to eIF2α phosphorylation and cellular protein translation arrest during DENV4 and ZIKV infection. …
日本脑炎病毒sfRNA靶向PKR和IFITM2的翻译抑制细胞干扰素应答
本研究旨在探究日本脑炎病毒(JEV)感染细胞后产生非编码亚基因组RNA(sfRNA)的生物学功能。应用Northern blot检测JEV感染细胞产生sfRNA的动态特征;通过Western blot和qPCR检测JEV感 …