Phospho-PLCγ1 (Tyr783) Antibody | Cell Signaling Technology
2025年3月25日 · Phosphorylation by Syk at Tyr783 activates the enzymatic activity of PLCγ1 (8). Explore pathways related to this product. CD28 shapes T cell receptor signaling by regulating …
磷脂酶 C 通路 | Cell Signaling Technology
磷酸肌醇特异性磷脂酶 C (PLC) 在跨膜信号转导中扮演重要角色。 响应细胞外刺激，如激素、生长因子和神经递质刺激后，PLC 水解磷脂酰肌醇-4,5 二磷酸 (PIP2) 并产生第二信使肌糖 1,4,5 …
A gain-of-function variation in PLCG1 causes a new immune
The PLCG1 activating variant resulted in enhanced NF-κB and type II interferon pathways in T cells, and hyperactivated NF-κB and type I interferon pathways in monocytes. Treatment with …
Gain-of-function variants in SYK cause immune dysregulation and ...
2021年3月29日 · We identified damaging monoallelic SYK variants in six patients with immune deficiency, multi-organ inflammatory disease such as colitis, arthritis and dermatitis, and …
Association study of genetic variants in PLA2G4A, PLCG1, LAT, SYK…
We studied the association of nine single nucleotide polymorphisms in five genes involved in mast cell activation (SYK, LAT1, PLCG1, PLA2G4A, and TNFRSF11A) in 450 NIUA patients and …
PLCG1 Gene - GeneCards | PLCG1 Protein | PLCG1 Antibody
2024年12月25日 · The receptor-mediated activation of PLCG1 involves its phosphorylation by tyrosine kinases, in response to ligation of a variety of growth factor receptors and immune …
Phosphorylation of PLCγ1 by EphA2 receptor tyrosine kinase …
2021年3月19日 · In this study, we used a yeast-two-hybrid screen to identify PLCγ1 as a novel EphA2 interactor. EphA2 interacts with PLCγ1 and the kinase activity of EphA2 was required …
Distinct Pathways Regulate Syk Protein Activation Downstream …
2015年5月1日 · In this study, we identified a novel signaling mechanism in CLEC-2-mediated Syk activation. CLEC-2-mediated, but not GPVI-mediated, platelet activation and Syk …
Association study of genetic variants in PLA2G4A, PLCG1, LAT ... - LWW
We studied the association of nine single nucleotide polymorphisms in five genes involved in mast cell activation (SYK, LAT1, PLCG1, PLA2G4A, and TNFRSF11A) in 450 NIUA patients and …
Phospho-PLCγ1 (Ser1248) Antibody | Cell Signaling Technology
5 天之前 · Phospho-PLCγ1 (Ser1248) Antibody detects PLCγ1 only when phosphorylated at Ser1248. Polyclonal antibodies are produced by immunizing animals with a synthetic …
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