Pyridoxal phosphate (PLP, pyridoxal 5'-phosphate, P5P), the active form of vitamin B 6, is a coenzyme in a variety of enzymatic reactions. The International Union of Biochemistry and Molecular Biology has catalogued more than 140 PLP-dependent activities, corresponding to ~4% of all classified activities. [5]

2024年8月24日 · The coenzyme pyridoxal phosphate (commonly abbreviated PLP) is the active form of vitamin B6 B 6, or pyridoxine. PLP is required for over 100 different reactions in human metabolism, primarily in the various amino acid biosynthetic and degradation pathways.

2023年6月20日 · 磷酸吡哆醛 (Pyridoxal 5′-phosphate, PLP) 依赖酶可催化多种化学反应，比如转氨、脱羧、外消旋、差向异构、[3 + 2] 环化 、β/γ 消除或置换、羟醛加成 、克莱森缩合 以及 O 2 依赖的氧化反应等等。PLP依赖酶之所以能发挥多种催化功能，主要是因为其辅因子PLP可以充当 ...

The vitamin B(6)-derived pyridoxal 5'-phosphate (PLP) is the cofactor of enzymes catalyzing a large variety of chemical reactions mainly involved in amino acid metabolism. These enzymes have been divided in five families and fold types on the basis of evolutionary relationships and protein structura …

2024年8月1日 · Pyridoxal-5′-phosphate (PLP) is arguably the most versatile enzymatic cofactor catalyzing transamination, decarboxylation, epimerization, retro-aldol chemistry, Claisen condensation, and a host of β- and γ-elimination/substitution reactions alongside O 2-dependent monooxygenation and oxidase reactions [1, 2, 3]. It achieves this reaction ...

The B6 coenzymes, composed of pyridoxal 5'-phosphate (PLP) and pyridoxamine 5'-phosphate (PMP), are used by many transaminases, racemases, decarboxylases, and enzymes catalyzing alpha,beta and beta,gamma-eliminations.

Pyridoxal 5′-phosphate (PLP; vitamin B 6) is a chromophoric cofactor required for catalytic activity by a wide variety of enzymes. 7,8 It typically exhibits absorption bands at ~430, ~360, and ~330 nm with extinction coefficients of ~5000 M −1 cm −1.

PLP, or pyridoxal 5'-phosphate, is a coenzyme derived from vitamin B6 that plays a crucial role in the catabolism of proteins through the process of deamination. It serves as a cofactor for numerous enzymes involved in amino acid metabolism.

Pyridoxal-5′-phosphate (PLP), the active form of vitamin B 6, is an important and versatile coenzyme involved in a variety of enzymatic reactions, accounting for about 4% of all classified activities. However, the detailed catalytic reaction pathways for PLP-dependent enzymes remain to …

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